Figures
- FIGURE 1
Kaplan–Maier curves for mortality during the study period corresponding to a) FACED score and b) bronchiectasis severity index score category.
- FIGURE 2
Receiver operating characteristic curves for bronchiectasis severity index (BSI) and FACED score for a) 5-, b) 10- and c) 15-year mortality.
Tables
- TABLE 1
Demographics of study cohort
Age years 52.5±12.4 FEV1 % predicted 68.8±27.7 BMI kg·m−2 23.4±3.9 MRC dyspnoea score 2.1±0.9 Lobes affected 3.4±1.5 Exacerbations in previous year 4.4±4.4 Hospitalisations in last 2 years 0.5±1.3 Microbiological colonisation status Pseudomonas aeruginosa 16 (22) Haemophilus influenzae 9 (12) Streptococcus pneumoniae 3 (4) Staphylococcus aureus 1 (1) Branhamella catarrhalis 1 (1) Aetiology of bronchiectasis Idiopathic 41 (55) Post-infective 19 (26) Allergic bronchopulmonary aspergillosis 5 (7) Young's syndrome 4 (5) Common variable immunodeficiency 3 (4) Primary ciliary dyskinesia 2 (3) Data are presented as mean±sd or n (%). FEV1: forced expiratory volume in 1 s; BMI: body mass index; MRC: Medical Research Council.
- TABLE 2
Classification of subjects by bronchiectasis severity index (BSI) and FACED scores
BSI FACED Mild Moderate Severe Mild 17 1 1 Moderate 21 10 1 Severe 11 8 4 Data are presented as n.
- TABLE 3
Contribution of individual variables to FACED and bronchiectasis severity index (BSI) scores
FACED score BSI score Mild
(0–2)Moderate
(3–4)Severe
(5–7)Mild
(0–4)Moderate
(5–8)Severe
(9+)Age years <50 22 (45) 8 (42) 1 (22) 11 (58) 14 (44) 7 (30) 50–69 25 (51) 8 (42) 3 (50) 8 (42) 14 (44) 13 (57) 70–79 2 (4) 3 (16) 2 (33) 0 (0) 4 (13) 3 (13) ≥80 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) FEV1 % predicted <30 2 (4) 3 (16) 2 (33) 1 (5) 4 (13) 2 (9) 30–49 2 (4) 12 (63) 3 (50) 2 (11) 9 (28) 7 (30) 50–80 18 (37) 3 (16) 1 (22) 4 (21) 9 (28) 10 (43) >80 27 (55) 1 (5) 0 (0) 12 (63) 10 (31) 4 (17) BMI kg·m−2 <18.5 1 (2) 2 ((11) 0 (0) 0 (0) 0 (0) 3 (13) 18.5–25 36 (73) 15 (79) 5 (87) 15 (79) 24 (75) 15 (65) 26–30 9 (18) 1 (5) 0 (0) 3 (16) 6 (19) 3 (13) >30 3 (6) 1 (5) 1 (22) 1 (5) 2 (6) 2 (6) MRC dyspnoea score 0–2 36 (73) 12 (63) 0 (0) 15 (79) 25 (78) 8 (35) 3 11 (22) 7 (37) 4 (66) 4 (21) 7 (22) 11 (48) 4 2 (4) 0 (0) 2 (33) 0 (0) 0 (0) 4 (17) 5 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) Lobes affected 1 6 (12) 1 (5) 0 (0) 3 (16) 2 (6) 2 (6) 2 16 (33) 3 (16) 0 (0) 5 (26) 8 (25) 6 (26) ≥3 or cystic bronchiectasis 27 (55) 15 (79) 6 (100) 11 (58) 22 (69) 15 (65) Exacerbations in previous year 0 3 (6) 2 (11) 1 (22) 3 (16) 3 (9) 0 (0) 1–2 17 (35) 5 (26) 3 (50) 13 (68) 7 (22) 6 (26) ≥3 29 (59) 12 (63) 2 (33) 3 (16) 22 (69) 17 (74) Hospitalisations in last 2 years Yes 15 (31) 3 (16) 1 (22) 0 (0) 7 (22) 12 (52) No 34 (69) 16 (84) 5 (87) 19 (100) 25 (78) 11 (48) Microbiological colonisation status Pseudomonas aeruginosa 6 (12) 5 (26) 5 (83) 1 (5) 7 (22) 8 (35) Haemophilus influenzae 6 (12) 3 (16%) 0 (0) 2 (11) 5 (16) 2 (9) Streptococcus pneumoniae 2 (4) 1 (5) 0 (0) 0 (0) 3 (9) 0 (0) Staphylococcus aureus 1 (2) 0 (0) 0 (0) 1 (5) 0 (0) 0 (0) Branhamella catarrhalis 1 (2) 0 (0) 0 (0) 1 (5) 0 (0) 0 (0) None 33 (67) 10 (53) 1 (17) 14 (74) 27 (84) 13 (57) Data are presented as n (%). FEV1: forced expiratory volume in 1 s; BMI: body mass index; MRC: Medical Research Council.
- TABLE 4
Univariate Cox proportional hazard analysis of bronchiectasis severity index (BSI) and FACED scores for mortality during the study period according to BSI and FACED category
Subjects
nMortality
n (%)Hazard ratio
(95% CI)p-value BSI Mild 19 4 (21%) Reference Moderate 32 9 (28%) 1.40 (0.43–4.54) 0.577 Severe 23 13 (57%) 3.66 (1.19–11.24) 0.023 FACED Mild 49 8 (16%) Reference Moderate 19 13 (68%) 5.90 (2.43–14.32) <0.001 Severe 6 5 (83%) 12.49 (3.98–39.18) <0.001 - TABLE 5
Comparison of receiver operating characteristics (ROCs) for mortality at different time points between bronchiectasis severity index (BSI) and FACED scores
Mortality BSI FACED p-value 5-year 0.79 (0.64–0.94) 0.80 (0.65–0.95) 0.876 10-year 0.71 (0.55–0.86) 0.84 (0.72–0.95) 0.082 15-year 0.69 (0.55–0.82) 0.82 (0.72–0.93) 0.049 Data are presented as area under the curve (95% CI), unless otherwise stated. p-values calculated using DeLong's test for two correlated ROC curves.
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