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Treatable traits: toward precision medicine of chronic airway diseases

Alvar Agusti, Elisabeth Bel, Mike Thomas, Claus Vogelmeier, Guy Brusselle, Stephen Holgate, Marc Humbert, Paul Jones, Peter G. Gibson, Jørgen Vestbo, Richard Beasley, Ian D. Pavord
European Respiratory Journal 2016 47: 410-419; DOI: 10.1183/13993003.01359-2015
Alvar Agusti
1Respiratory Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona and CIBER Enfermedades Respiratorias (CIBERES), Spain
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  • For correspondence: Alvar.Agusti@clinic.ub.es
Elisabeth Bel
2Dept of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
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Mike Thomas
3Primary Care and Population Sciences, University of Southampton, Southampton, UK
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Claus Vogelmeier
4Dept of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-Universität Marburg, and Member of the German Center for Lung Research (DZL), Germany
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Guy Brusselle
5Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
6Depts of Epidemiology and Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
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Stephen Holgate
7Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
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Marc Humbert
8Université Paris-Sud; Service de Pneumologie, Hôpital Bicêtre (Assistance Publique-Hôpitaux de Paris); INSERM UMR_S 999, Le Kremlin-Bicêtre, France
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  • ORCID record for Marc Humbert
Paul Jones
9St George's University of London, London, UK
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Peter G. Gibson
10Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Hunter Medical Research Institute, and Priority Research Centre for Asthma and Respiratory Disease, The University of Newcastle, NSW, Australia
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Jørgen Vestbo
11Centre for Respiratory Medicine and Allergy, Manchester Academic Health Science Centre, University Hospital South Manchester NHS Foundation Trust, Manchester, UK
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Richard Beasley
12Medical Research Institute of New Zealand, Wellington, New Zealand
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Ian D. Pavord
13Respiratory Medicine Unit, NDM Research Building, Nuffield Dept of Medicine, University of Oxford, Oxford, UK
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Abstract

Asthma and chronic obstructive pulmonary disease (COPD) are two prevalent chronic airway diseases that have a high personal and social impact. They likely represent a continuum of different diseases that may share biological mechanisms (i.e. endotypes), and present similar clinical, functional, imaging and/or biological features that can be observed (i.e. phenotypes) which require individualised treatment. Precision medicine is defined as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations”. In this Perspective, we propose a precision medicine strategy for chronic airway diseases in general, and asthma and COPD in particular.

Abstract

A discussion of the concept of “treatable traits” as a way towards precision medicine of chronic airway diseases http://ow.ly/UbJAm

Footnotes

  • For editorial comment see Eur Respir J 2016; 47: 359–361 [DOI: 10.1183/13993003.01930-2015].

  • Support statement: A. Agusti is supported by Instituto de Salud Carlos III (PI12/01117), Recercaixa-2012 (AA084096), SEPAR (PI065/2013, PI192/2012) and FUCAP 2012; M. Thomas is supported by the NIHR Southampton Biomedical Research Unit, NIHR Wessex CLAHRC; M. Humbert is supported by Université Paris-Sud, INSERM and AP-HP (DHU Thorax Innovation); R. Beasley is supported by HRC NZ IRO grant.

  • Conflict of interest: Disclosures can be found alongside the online version of this article at erj.ersjournals.com

  • Received August 15, 2015.
  • Accepted October 27, 2015.
  • Copyright ©ERS 2016
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Treatable traits: toward precision medicine of chronic airway diseases
Alvar Agusti, Elisabeth Bel, Mike Thomas, Claus Vogelmeier, Guy Brusselle, Stephen Holgate, Marc Humbert, Paul Jones, Peter G. Gibson, Jørgen Vestbo, Richard Beasley, Ian D. Pavord
European Respiratory Journal Feb 2016, 47 (2) 410-419; DOI: 10.1183/13993003.01359-2015

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Treatable traits: toward precision medicine of chronic airway diseases
Alvar Agusti, Elisabeth Bel, Mike Thomas, Claus Vogelmeier, Guy Brusselle, Stephen Holgate, Marc Humbert, Paul Jones, Peter G. Gibson, Jørgen Vestbo, Richard Beasley, Ian D. Pavord
European Respiratory Journal Feb 2016, 47 (2) 410-419; DOI: 10.1183/13993003.01359-2015
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Precision medicine of chronic airway diseases: why?
    • Limitations of current diagnostic labels: one size does not fit all
    • Treatable traits: a label-free, precision medicine approach to the diagnosis and management of chronic airway diseases
    • Potential limitations
    • Conclusions
    • Acknowledgements
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