Abstract
Innovative solutions are required for TB R&D to ensure the bold targets outlined in the WHO END TB strategy are met http://ow.ly/TLTmQ
To the Editor:
The recent article by Barnes et al. [1] discussing barriers to new drug development in respiratory disease is particularly pertinent to the concerning situation for new tuberculosis (TB) drugs. In Médecins Sans Frontières (MSF)'s project in Karakalpakstan, Uzbekistan, 38% of new patients present with multidrug-resistant (MDR)-TB [2]. The need for new TB drugs and regimens has never been greater, with treatment success rates of only 48% for MDR-TB patients and <20% for extensively drug-resistant (XDR)-TB [3]. Despite two new compounds, bedaquiline and delamanid, being approved for the treatment of MDR-TB [4], the pipeline for new TB drugs is inadequate. Many compounds in phase II and IIl development are repurposed antibiotics, and may have pre-existing resistance (figure 1).
Bedaquiline and delamanid have not been studied together and are being added to the existing weak regimen with companion drugs that have limited efficacy data in TB [6]. The danger of this is already being seen with the first cases of bedaquiline resistance being reported [7]. What is needed are new compounds developed as part of new combinations to treat all forms of TB.
The added challenge with TB research and development (R&D) is the lack of funding. Only 30% of the WHO's funding target for TB R&D is being invested annually [8]. Between 2011 and 2013, the total investment by commercial developers in R&D for new TB drugs declined, in part due to the withdrawal of large pharmaceutical companies from TB [8].
MSF, working with key stakeholders in TB drug development, has developed a proposal to address these gaps. The “Pull, Push, Pool” (3P) project aims to speed up development and ensure affordable access to new, effective and safe treatments for all forms of TB through a collaborative framework combining pull funding, push funding and a pooling mechanism for scientific knowledge and intellectual property (IP). Push, pull and pooling incentives have been used previously; for example, the UNITAID Medicines Patent Pool for HIV/AIDS medicines and the Xprize initiative (www.xprize.org/prizes). By combining these various incentives 3P aims to address the barriers in TB regimen development.
To fill the pipeline and encourage development of phase I TB compounds, milestone prizes (estimated range per prize of $40–70 million) will be offered for TB compounds that enter early clinical development. To facilitate early regimen development, licenses will be negotiated for the TB indication of the new phase I compounds and pooling the IP will facilitate the development of a range of new TB compounds as regimens. To be eligible for a prize, data and IP must be pooled. Finally, research grants for regimen development will be provided throughout the R&D process, encouraging clinical trials on novel regimens rather than individual compounds. The successful regimens developed in this system will have been financed upfront through grants and prizes, so will be rapidly available for affordable generic production by qualified manufacturers.
The major risks of the 3P project are in the ambition that donors have for it. If the incentives are insufficient to ensure adequate numbers of compounds arrive at phase I and if insufficient funding for regimen development in subsequent phases is provided, the project will not succeed. However, the project can start without the full allocation of funding in place and as prizes reward success, it allows more risk-averse funders, including governments, to fund elements of the proposal.
The needs of TB treatment, particularly MDR-TB, are great; the current system is under-resourced and not fit for purpose. New and innovative solutions [9] are required to ensure we are adequately prepared to meet the bold targets outlined in the WHO END TB strategy [10], and we hope the European Respiratory Society supports this initiative.
Footnotes
Conflict of interest: Disclosures can be found alongside the online version of this article at erj.ersjournals.com
- Received May 19, 2015.
- Accepted July 2, 2015.
- Copyright ©ERS 2016