Age years |
Sex |
Cough: persistent and unremitting cough of ≥14 days’ duration |
Weight loss: reported loss of weight by carer and/or objective evidence from child's growth chart with documented crossing of percentile line in the preceding 3 months |
Fever: report of persistent fever (>1 week) by carer and/or temperature ≥38°C at clinic evaluation |
Night sweats: drenching night sweat as indicated by soaked bedsheets or the clothing of the child |
Fatigue/malaise: persistent, unexplained reduced playfulness in an otherwise active child |
Lymphadenopathy: palpably enlarged cervical and/or other peripheral lymph nodes ≥2 cm in diameter (except inguinal lymph nodes) |
Abnormal chest radiograph: independent report of abnormality that is consistent with active tuberculosis disease by two study physicians, with any discordant report assessed by a third senior clinician blinded to the clinic data of the index child |
BCG vaccination: BCG scar seen on the left deltoid region and/or documented evidence of vaccination in child's immunisation card. |
BMI-for-age z-score: BMI adjusted for age and sex using the WHO 2007 reference standard |
Height-for-age z-score: height adjusted for age and sex the using WHO 2007 reference standard |
Positive TST: skin test induration ≥10 mm |
Positive IFN-γ response: Mycobacterium tuberculosis antigen-specific IFN-γ values ≥155.0 pg·mL−1 |