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Relationship between radiologic patterns, pulmonary function values and BALF cells in newly diagnosed sarcoidosis

Regina Aleksoniene, Ingrida Zeleckiene, Mindaugas Mataciunas, Roma Puronaite, Edvardas Danila
European Respiratory Journal 2015 46: PA846; DOI: 10.1183/13993003.congress-2015.PA846
Regina Aleksoniene
1Clinic of Infectious, Chest Diseases, Dermatovenereology and Allergology; Centre of Pulmonology and Allergology, Vilnius University; Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
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Ingrida Zeleckiene
2Radiology and Nuclear Medicine Centre, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
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Mindaugas Mataciunas
2Radiology and Nuclear Medicine Centre, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
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Roma Puronaite
3Centre of Informatics and Development, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
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Edvardas Danila
1Clinic of Infectious, Chest Diseases, Dermatovenereology and Allergology; Centre of Pulmonology and Allergology, Vilnius University; Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania
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Abstract

Aim of the study: To evaluate interface between radiologic changes, pulmonary function impairment and bronchoalveolar lavage fluid (BALF) cells in sarcoidosis patients.

Materials and methods: 80 patients with newly diagnosed sarcoidosis (41 F, 39 M, age 39±9 yrs) were included. Patients underwent CT scanning, pulmonary function tests (PFT) and BAL. Correlations between CT patterns, PFT values and BALF cells were analysed.

Results: Statistically significant differences between FVC (p=0.040), FEV1 (p=0.017), TLC (p=0.049), VC (p=0.015), DLCO (p=0.012) and BALF neutrophil count (p=0.02) were found in different radiographic stages of sarcoidosis. PFT values were decreased in stage III compared with stage I patients.

Correlations between consolidation, ground glass opacities on CT and FVC (r=-2.227, p=0.043), FEV1 (r=-0.299, p=0.007), FEV1/FVC (r=-0.245, p=0.029), DLCO (r=-267, p=0.017) were established. Micronodules, macronodules and linear opacities didn't correlate with PFT values or BALF cell count. There was a negative correlation between lymph nodes calcinosis and FEV1 (p=0.004). In cases of atypical lymphadenopathy BALF neutrophil count tended to be increased.

BALF lymphocytes elevation (r=-0.272, p=0.020), decrease of macrophage count (r=0.271, p=0.020) was associated with decreased TLC values. Typical lymphadenopathy localization was associated with increase of CD4/CD8 ratio.

CD8 (p=0.005) increase, CD4 (p=0.035) and the CD4/CD8 ratio (p=0.011) decrease was found in smoking patients compared with non-smokers in stage II.

Conclusions: A strong interface between radiologic changes, pulmonary function impairment and BALF cells exists in sarcoidosis patients.

  • Sarcoidosis
  • Bronchoalveolar lavage
  • Lung function testing
  • Copyright ©ERS 2015
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Relationship between radiologic patterns, pulmonary function values and BALF cells in newly diagnosed sarcoidosis
Regina Aleksoniene, Ingrida Zeleckiene, Mindaugas Mataciunas, Roma Puronaite, Edvardas Danila
European Respiratory Journal Sep 2015, 46 (suppl 59) PA846; DOI: 10.1183/13993003.congress-2015.PA846

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Relationship between radiologic patterns, pulmonary function values and BALF cells in newly diagnosed sarcoidosis
Regina Aleksoniene, Ingrida Zeleckiene, Mindaugas Mataciunas, Roma Puronaite, Edvardas Danila
European Respiratory Journal Sep 2015, 46 (suppl 59) PA846; DOI: 10.1183/13993003.congress-2015.PA846
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