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Predictive factors of a positive methacholine challenge response based on data from a baseline respiratory function test

Rute Morgado, Cátia Oliveira, Rafaela Campanha, Susana Moreira, Richard Staats, Dina Escaleira, João Valença, Cristina Bárbara
European Respiratory Journal 2015 46: PA609; DOI: 10.1183/13993003.congress-2015.PA609
Rute Morgado
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Cátia Oliveira
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Rafaela Campanha
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Susana Moreira
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Richard Staats
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Dina Escaleira
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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João Valença
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Cristina Bárbara
Pulmonology Department, Centro Hospitalar Lisboa Norte, Lisbon, Portugal
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Abstract

Airway hyperresponsiveness (AHR) is defined as an excessive response to an aerosolized drug provocation that elicits little or no response in a normal person. The methacholine (MCH) challenge is a method of assessing AHR, which is one of the features that contributes to the diagnosis of asthma. However, MCH challenge has some handicaps: high economic costs, a complex process of preparation, a limited availability of the drug and a long evaluation time with a qualified technician.

The aim of this study was to identify the predictive factors of a positive MCH challenge based on the data from a baseline respiratory function test.

Between 2011 and 2015, a total of 447 patients underwent MCH challenge test (equipment: Masterscreen VIASYS with APS) after performing a baseline respiratory function test (according to the criteria of the ATS 1999). The test was considered positive when the result of the PD20 was between < 0,1 µmol and 7.8 µmol. The statistic significance was evaluated with the T-test.

A positive MCH challenge, based on ATS FEV1 criteria, was observed in 252 subjects (56,4%). A positive MCH challenge correlated statistically with age (p=0,000), FEV1% (p=0,001), FEF50% (p=0,001), RV% (p=0,049) and airway resistance Raw (p=0,005). On the other side, lung inflation and specific conductance sGaw had no correlation with the MCH challenge.

The predictive factors of a positive response to a MCH challenge are extremely important, since they may be the base of future guidelines to identify the patients that will benefit from this test. This will allow a rationale use of a complex and expensive resource with an improvement in the healthcare efficiency.

  • Asthma - diagnosis
  • Breath test
  • Monitoring
  • Copyright ©ERS 2015
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Predictive factors of a positive methacholine challenge response based on data from a baseline respiratory function test
Rute Morgado, Cátia Oliveira, Rafaela Campanha, Susana Moreira, Richard Staats, Dina Escaleira, João Valença, Cristina Bárbara
European Respiratory Journal Sep 2015, 46 (suppl 59) PA609; DOI: 10.1183/13993003.congress-2015.PA609

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Predictive factors of a positive methacholine challenge response based on data from a baseline respiratory function test
Rute Morgado, Cátia Oliveira, Rafaela Campanha, Susana Moreira, Richard Staats, Dina Escaleira, João Valença, Cristina Bárbara
European Respiratory Journal Sep 2015, 46 (suppl 59) PA609; DOI: 10.1183/13993003.congress-2015.PA609
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