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Activin-A BAL levels and Immunochemistry for activin A receptors in patients with asthma

Anastasia Papaporfyriou, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Philip Emmanouil, Konstantina Kontogianni, Elissavet Konstantellou, Georgios Hillas, Patroklos Katafygiotis, Rodoula Trigidou, Nikolaos Koulouris, Spyridon Papiris, Stelios Loukidis
European Respiratory Journal 2015 46: PA595; DOI: 10.1183/13993003.congress-2015.PA595
Anastasia Papaporfyriou
12nd Respiratory Medicine Attiko University Hospital, University of Athens Medical School, Athens, Greece
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Petros Bakakos
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Konstantinos Kostikas
12nd Respiratory Medicine Attiko University Hospital, University of Athens Medical School, Athens, Greece
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Georgios Papatheodorou
3Microbiology, 401 Military Hospital, Athens, Greece
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Philip Emmanouil
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Konstantina Kontogianni
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Elissavet Konstantellou
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Georgios Hillas
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Patroklos Katafygiotis
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Rodoula Trigidou
4Pathology, Sotiria Chest Hospital, Athens, Greece
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Nikolaos Koulouris
21st Respiratory Medicine, Sotiria Chest Hospital, University of Athens Medical School, Athens, Greece
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Spyridon Papiris
12nd Respiratory Medicine Attiko University Hospital, University of Athens Medical School, Athens, Greece
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Stelios Loukidis
12nd Respiratory Medicine Attiko University Hospital, University of Athens Medical School, Athens, Greece
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Abstract

Introduction: Activin A is implicated in the remodeling processes. It exerts its biological effects though activation of transmembrane serine/threonine kinase receptors.

Aim: To investigate both Activin A BAL levels and receptors' staining and to determine whether any upregulated expression is implicated in the remodeling processes.

Methods: 12 patients with Severe Refractory [SRA] and 11 with mild to moderate disease were studied. All subjects underwent bronchoscopy. In BAL activin-A, cell counts, IL-8, TGF-β1, ECP and IL-13, were assessed. Smooth muscle area (SMA), reticular basement membrane (RBM) thickness and the length of epithelial detachment (ED) in bronchial biopsies of asthmatics with different underlying severity were assessed. Biopsies were stained with antibodies for ActRIIΑ, ActIIB and ALK-4. Possible associations with inflammatory cells and mediators in BAL were also assessed. All sections were analyzed with image analysis.

Results: Activin-A was significantly increased in BAL of patients with SRA compared to mild and moderate ones [median IQR, 193 (87-264) vs 35(22-93), p<0.001]. Using regression analysis a positive association between Activin-A increased SMA, ED and levels of IL-13 were observed. ALK-4 receptor was highly expressed in patients with SRA compared to mild to moderate ones.

Conclusions: ALK-4 seems to be the major receptor for Activin-A signaling in airway epithelium. Activin-A is implicated in the remodeling process in patients with SRA.

  • Asthma - mechanism
  • Biomarkers
  • Airway management
  • Copyright ©ERS 2015
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Activin-A BAL levels and Immunochemistry for activin A receptors in patients with asthma
Anastasia Papaporfyriou, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Philip Emmanouil, Konstantina Kontogianni, Elissavet Konstantellou, Georgios Hillas, Patroklos Katafygiotis, Rodoula Trigidou, Nikolaos Koulouris, Spyridon Papiris, Stelios Loukidis
European Respiratory Journal Sep 2015, 46 (suppl 59) PA595; DOI: 10.1183/13993003.congress-2015.PA595

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Activin-A BAL levels and Immunochemistry for activin A receptors in patients with asthma
Anastasia Papaporfyriou, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Philip Emmanouil, Konstantina Kontogianni, Elissavet Konstantellou, Georgios Hillas, Patroklos Katafygiotis, Rodoula Trigidou, Nikolaos Koulouris, Spyridon Papiris, Stelios Loukidis
European Respiratory Journal Sep 2015, 46 (suppl 59) PA595; DOI: 10.1183/13993003.congress-2015.PA595
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