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Clinical and therapeutic characteristics of patients died due to radiation-induced pneumonitis

David Yabar, Arturo Navarro, Susana Padrones, Ramón Palmero, Jordi Dorca, Samantha Aso
European Respiratory Journal 2015 46: PA4835; DOI: 10.1183/13993003.congress-2015.PA4835
David Yabar
1Pulmonology, Hospital Universitari de Bellvitge, Barcelona, Cataluña Spain
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Arturo Navarro
2Oncology, Institut Català d'Oncologia, Barcelona, Cataluña Spain
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Susana Padrones
1Pulmonology, Hospital Universitari de Bellvitge, Barcelona, Cataluña Spain
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Ramón Palmero
2Oncology, Institut Català d'Oncologia, Barcelona, Cataluña Spain
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Jordi Dorca
1Pulmonology, Hospital Universitari de Bellvitge, Barcelona, Cataluña Spain
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Samantha Aso
1Pulmonology, Hospital Universitari de Bellvitge, Barcelona, Cataluña Spain
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Abstract

Introduction: The main limitation of radiotherapy (RT) in lung cancer treatment is the radiation-induced lung disease (RILD), with 15% of mortality. The aim to this study is to describe the clinical and therapeutic characteristics of patients died due to RILD and to identify possible factors that may be related to its mortality.

Materials and Methods: Case-control study (2013-2014) with 28 patients who received radical chemo-radiotherapy. Cases included 14 patients died due to RILD. Clinical, therapeutic characteristics and pulmonary function were evaluated. The Radiation Theraphy Oncology Group (RTOG) scale was used for its severity.

Results: Table nº1 shows demographic and clinical characteristics and pulmonary function . The table nº2 shows characteristics of the treatment .

FeaturesControls (n=14)Cases (n=14)p value
Age (years)65,969,90,164
Sex (M/F)11/312/20,621
Smoking habit13 (92,9%)14 (100%)0,309
Arterial hypertension4 (28,6%)8 (57,1%)0,127
Diabetes Mellitus3 (21,4%)2 (14,3%)0,622
FVC (mL)3134,330600,609
FVC (%)89,687,40,767
FEV1 (mL)2047,91953,60,467
FEV1 (%)75,6730,572

Demographic, clinical characteristics and pulmonary function of the 28 patients

FeaturesControls (n=14)Cases (n=14)p value
Mean lung dose (Gy)13,818,50,012
Maximun lung dose (Gy)67,362,20,061
Total lung volume (mL)3451,33235,10,527
V5 (%)51,162,50,038
V20 (%)23,330,30,045
RTOG (0-1)8 (61,5%)00,001
RTOG (2-5)5 (38,5%)14 (100%)0,001

Characteristics of the treatment of the 28 patients

Conclusions: RILD mortality is associated with radiotherapy mean lung dose, V5, V20 and a RTOG score over 2. There was no statistical relevance in pulmonary function and cardiovascular risk factors.

  • Lung cancer / Oncology
  • Neoplastic diseases
  • Thoracic oncology
  • Copyright ©ERS 2015
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Clinical and therapeutic characteristics of patients died due to radiation-induced pneumonitis
David Yabar, Arturo Navarro, Susana Padrones, Ramón Palmero, Jordi Dorca, Samantha Aso
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4835; DOI: 10.1183/13993003.congress-2015.PA4835

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Clinical and therapeutic characteristics of patients died due to radiation-induced pneumonitis
David Yabar, Arturo Navarro, Susana Padrones, Ramón Palmero, Jordi Dorca, Samantha Aso
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4835; DOI: 10.1183/13993003.congress-2015.PA4835
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