Abstract
Introduction: The main limitation of radiotherapy (RT) in lung cancer treatment is the radiation-induced lung disease (RILD), with 15% of mortality. The aim to this study is to describe the clinical and therapeutic characteristics of patients died due to RILD and to identify possible factors that may be related to its mortality.
Materials and Methods: Case-control study (2013-2014) with 28 patients who received radical chemo-radiotherapy. Cases included 14 patients died due to RILD. Clinical, therapeutic characteristics and pulmonary function were evaluated. The Radiation Theraphy Oncology Group (RTOG) scale was used for its severity.
Results: Table nº1 shows demographic and clinical characteristics and pulmonary function . The table nº2 shows characteristics of the treatment .
| Features | Controls (n=14) | Cases (n=14) | p value |
| Age (years) | 65,9 | 69,9 | 0,164 |
| Sex (M/F) | 11/3 | 12/2 | 0,621 |
| Smoking habit | 13 (92,9%) | 14 (100%) | 0,309 |
| Arterial hypertension | 4 (28,6%) | 8 (57,1%) | 0,127 |
| Diabetes Mellitus | 3 (21,4%) | 2 (14,3%) | 0,622 |
| FVC (mL) | 3134,3 | 3060 | 0,609 |
| FVC (%) | 89,6 | 87,4 | 0,767 |
| FEV1 (mL) | 2047,9 | 1953,6 | 0,467 |
| FEV1 (%) | 75,6 | 73 | 0,572 |
Demographic, clinical characteristics and pulmonary function of the 28 patients
| Features | Controls (n=14) | Cases (n=14) | p value |
| Mean lung dose (Gy) | 13,8 | 18,5 | 0,012 |
| Maximun lung dose (Gy) | 67,3 | 62,2 | 0,061 |
| Total lung volume (mL) | 3451,3 | 3235,1 | 0,527 |
| V5 (%) | 51,1 | 62,5 | 0,038 |
| V20 (%) | 23,3 | 30,3 | 0,045 |
| RTOG (0-1) | 8 (61,5%) | 0 | 0,001 |
| RTOG (2-5) | 5 (38,5%) | 14 (100%) | 0,001 |
Characteristics of the treatment of the 28 patients
Conclusions: RILD mortality is associated with radiotherapy mean lung dose, V5, V20 and a RTOG score over 2. There was no statistical relevance in pulmonary function and cardiovascular risk factors.
- Copyright ©ERS 2015
