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Determination of normal values for an isocapnic hyperventilation endurance test

Marjolaine Vincent, Isabelle Court Fortune, Jean Philippe Camdessanche, Frédéric Costes
European Respiratory Journal 2015 46: PA4613; DOI: 10.1183/13993003.congress-2015.PA4613
Marjolaine Vincent
1Service de Physiologie Clinique et Exercice, CHU Saint Etienne, Saint Etienne, France
2Service de Pneumologie et d'Oncologie Thoracique, CHU Saint Etienne, Saint Etienne, France
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Isabelle Court Fortune
2Service de Pneumologie et d'Oncologie Thoracique, CHU Saint Etienne, Saint Etienne, France
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Jean Philippe Camdessanche
3Service de Neurologie, CHU Saint Etienne, Saint Etienne, France
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Frédéric Costes
1Service de Physiologie Clinique et Exercice, CHU Saint Etienne, Saint Etienne, France
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Abstract

Aim: Evaluation of respiratory muscle function relies mainly on maximal inspiratory/expiratory pressures (MIP/MEP). However, their sensitivity to detect respiratory muscle weakness is low. Alternatively, it has been proposed to assess diaphragmatic performance through a progressive isocapnic hyperventilation test. However, normal values for this test are lacking precluding its use in a clinical setting.

Subjects and methods: We measured spirometry, MIP, MEP and maximal pressure during a snif-test according to recommendations. Isocapnic hyperventilation was performed using a Spirotiger® device in healthy volunteers. The subjects were asked to breathe in a rebreathing bag at a fixed tidal volume and predetermined levels of ventilation were reached by changing breathing frequency (fb). The test began at 30% of predicted maximal voluntary ventilation (MVV), and fb was then increased every 3 min to reach the target ventilation, up to MVV. The test was stopped when the subjects could no longer hyperventilate and sustain the target fb. Endurance time was expressed as Tlim in minutes and as the percentage of MVV sustained (%MVV).

Results: We studied 58 subjects (23 males), aged 44±17 yrs [range 25-77]. Mean Tlim was 21±7 min [6-30] and reached on average 88±24% MVV. Tlim%MVV was significantly related to MIP (R=0.42, p=0.003) and MEP (R=0.34, p=0.02) but not to SNIP (p=0.975).

Conclusions: These preliminary results showed that the evaluation of respiratory muscle endurance is feasible using this hyperventilation test using an incremental protocol up to task failure. Normative values according to age should be derived from a larger group of subjects, which will allow to detect diaphragmatic weakness in patients.

  • Respiratory muscle
  • Physiology
  • Lung function testing
  • Copyright ©ERS 2015
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Determination of normal values for an isocapnic hyperventilation endurance test
Marjolaine Vincent, Isabelle Court Fortune, Jean Philippe Camdessanche, Frédéric Costes
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4613; DOI: 10.1183/13993003.congress-2015.PA4613

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Determination of normal values for an isocapnic hyperventilation endurance test
Marjolaine Vincent, Isabelle Court Fortune, Jean Philippe Camdessanche, Frédéric Costes
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4613; DOI: 10.1183/13993003.congress-2015.PA4613
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