Abstract
Association between smoking, COPD and Pulmonary tuberculosis (PT) is often under estimated. Most of patients with PT are smokers and may often have co-morbidity as COPD.
Aims: to evaluate the effect of smoking and COPD on outcomes of diffusion lung capacity in patients with PT
Methods: 82 patients with PT with infiltrates in 1-3 segments and disease duratuion till 1 year are examined. 1 group - 35 non-smokers, 2 - 29 smokers without signs of COPD (9,0 pack-years of smoking, 95% CI 3,7-14,3), 3 - 18 patients with COPD (37,8 pack-years, 95% CI 19,3-56,2). We used spirometry, bodyplethysmography, measurement of diffusion capacity for carbon monoxide by single breath method (DLCO) on MasterScreen Body Diffusion (VIASYS healthcare), Computed tomography on TOSHIBA AQUILION 32. We used descriptive statistics and Spearman correlation analysis (Statistica, statSoft Inc., USA).
Results: There were not significant ventilation disorders in groups 1 and 2. DLCO was moderately decreased in both groups. But only non-smokers had significantly more DLCO vs patients with COPD (78,7±11,2 vs 66,7±11,3, p<0,05). DLCO in smokers and COPD patients was not significantly different (74,4±11,7 vs 66,7±11,3, p>0,05). There was an increase in hemoglobin from group 1 to 3 (12,8; 14,2; 15,2; p<0,01 gr. 1 and 2, gr. 1 and 3). The correlation analysis revealed an association between DLCO, air trapping volume, Hb and the pack-years of smoking (-0,41; 0,37; 0,45; p<0,05).
Conclusions: The patients who had the association COPD and PT had most significant decrease of DLCO, but mean value of DLCO in smokers and COPD patients was not significantly different. DLCO decreasing was associated with the pack-years of smoking.
- Copyright ©ERS 2015
