Abstract
Introduction: Lung cancer remains the leading human cancer worldwide with a high rate of mortality .When diagnosis is made early, surgical treatment may have a huge benefit on survival.
Aims: To identify surgical treatment outcomes on patients with early stage of non small cell lung cancer (NSCLC).
Method: A cohort study carried out in our pneumology department; we enrolled 90 patients diagnosed with early stage NSCLC between 2003 and 2012.
Results: The medium age was 60 y with male predominance. Tobacco smoking interested 88% of our patients. Chronic respiratory disease was the major comorbidity especially COPD(21%).Main symptoms were cough (62%)and chest pain(54%).Consultation delay average was 2 months.97% of patients had PS 0-1.Positive diagnosis was done through fiberscopy in 28% of cases, transthoracic biopsy in 42%, surgical biopsy in 30% and mediastinoscopy in 10%. Adenocarcinoma was the predominant histological type(60%). Confirmation delay was about 22d. Classification: Ia 7%;Ib17%;IIa11%;IIb34%;IIIa31%.Surgery was the first option treatment in 78% of cases. Survival average delay was about 47 months in these patients versus 11 months for non operated patients(p=0.001).This delay was even better in the group of patients who received adjuvant chemotherapy: 67 months vs 51months(p<0.05).However, neoadjuvant chemotherapy didn't have a positive effect on survival.
Conclusion: It is clear that surgery have positive outcomes on survival within early stages of NSCLC especially when associated to adjuvant chemotherapy.
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