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Development of lung function in infancy in 'healthy' preterm infants

Ines De Mir, Olaia Sardon, Paula Corcuera, Manuel Sanchez Solís, Araceli Caballero, A.F. Hoo, Virginia Pérez, Eduardo González Perez-Yarza, Antonio Moreno-Galdó
European Respiratory Journal 2015 46: PA4154; DOI: 10.1183/13993003.congress-2015.PA4154
Ines De Mir
1Pediatric Pulmonology Unit, Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Olaia Sardon
2Division of Pediatric Respiratory Medicine. Department of Pediatrics, Hospital Universitario Donostia. University of the Basque Country, San Sebastian, Spain
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Paula Corcuera
2Division of Pediatric Respiratory Medicine. Department of Pediatrics, Hospital Universitario Donostia. University of the Basque Country, San Sebastian, Spain
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Manuel Sanchez Solís
3Pediatric Respiratory Unit. Department of Pediatrics. Universidad de Murcia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
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Araceli Caballero
1Pediatric Pulmonology Unit, Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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A.F. Hoo
4Respiratory, Critical Care & Anaesthesia Section, UCL, Institute of Child Health, London, United Kingdom
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Virginia Pérez
3Pediatric Respiratory Unit. Department of Pediatrics. Universidad de Murcia, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain
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Eduardo González Perez-Yarza
2Division of Pediatric Respiratory Medicine. Department of Pediatrics, Hospital Universitario Donostia. University of the Basque Country, San Sebastian, Spain
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Antonio Moreno-Galdó
1Pediatric Pulmonology Unit, Hospital Universitari Vall d'Hebron. Universitat Autònoma de Barcelona, Barcelona, Spain
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Abstract

Even in the absence of overt respiratory disease during the neonatal period, reduced lung function (LF) has been reported in preterm infants. We have previously found significantly lower Crs, V'maxFRC, FEV0.5 and FEF25-75 in “healthy” preterm infants when compared to term controls (ERS de Mir, 2014)

Objectives: To assess LF at 6 and 18 months of age in preterm infants without neonatal respiratory disease, and compare the measurements to those obtained in healthy fullterm infants.

Methods: LF was measured under chloral sedation in 'healthy' preterm (30-35.8 w) and fullterm Spanish White babies, using the CareFusionTM Masterscreen BabyBody equipment. Results were expressed as z scores to adjust for sex, age and body size (Lum, Ped Pulm 2010; Nguyen, Ped Pulm 2013).

Results: 156 infants were initially studied at mean (SD) corrected postnatal age (cPNA) of 5.9 (1.0) months. 112 (57 term and 55 preterm) were followed up at 18.3 and 18.2 months respectively. At 18 months cPNA, results were similar between the groups

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LFT follow up at 18 m cPNA

Conclusions: The differences observed in our cohort between term controls and 'healthy' preterm infants at 6 months cPNA in Crs, V'maxFRC, FEV 0,5 and FEF 25-75% was no longer evident at 18 months corrected age, suggesting a catch-up of lung function in this group of preterm infants.

  • Lung function testing
  • Infants
  • Copyright ©ERS 2015
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Development of lung function in infancy in 'healthy' preterm infants
Ines De Mir, Olaia Sardon, Paula Corcuera, Manuel Sanchez Solís, Araceli Caballero, A.F. Hoo, Virginia Pérez, Eduardo González Perez-Yarza, Antonio Moreno-Galdó
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4154; DOI: 10.1183/13993003.congress-2015.PA4154

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Development of lung function in infancy in 'healthy' preterm infants
Ines De Mir, Olaia Sardon, Paula Corcuera, Manuel Sanchez Solís, Araceli Caballero, A.F. Hoo, Virginia Pérez, Eduardo González Perez-Yarza, Antonio Moreno-Galdó
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4154; DOI: 10.1183/13993003.congress-2015.PA4154
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