Abstract
Our drug-gas containing 8% CO2 in air combined with perfluorooctylbromide (Perflubron) vapor is being developed as a new class of fast acting bronchodilator drug working via unique biophysical mechanisms.
The revolutionary portable delivery device incorporates separate storage of a compressed gas cylinder and a drug-liquid ampoule within the device body.
On activation, compressed drug-gas is released through the liquid reservoir where perflubron vapor evaporates through an intermediate aerosol stage. The combined gas and vapor mixture is then delivered to a tidally breathing patient at a controlled dosing rate and multi-minute treatment time.
SAMi is developing this portable rescue device to treat severe bronchoconstriction as a first line emergency treatment to complement and enhance the activity of other drugs, particularly when conventional drugs have failed.
This is the first time a therapeutic drug gas combines with a therapeutic drug vapor in a revolutionary portable delivery device to treat respiratory disease.
- Copyright ©ERS 2015
