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First in class, respiratory drug gas & drug vapor delivered in a revolutionary and new portable device

John Dennis, Andy Clark, Ian McAffer, Stefan Dalberg, Francis Green
European Respiratory Journal 2015 46: PA4035; DOI: 10.1183/13993003.congress-2015.PA4035
John Dennis
1Main Department, SolAeroMed Inc (SAMi), Calgary, AB Canada
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Andy Clark
1Main Department, SolAeroMed Inc (SAMi), Calgary, AB Canada
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Ian McAffer
1Main Department, SolAeroMed Inc (SAMi), Calgary, AB Canada
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Stefan Dalberg
2Device Innovation, SAIT, Calgary, AB Canada
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Francis Green
1Main Department, SolAeroMed Inc (SAMi), Calgary, AB Canada
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Abstract

Our drug-gas containing 8% CO2 in air combined with perfluorooctylbromide (Perflubron) vapor is being developed as a new class of fast acting bronchodilator drug working via unique biophysical mechanisms.

The revolutionary portable delivery device incorporates separate storage of a compressed gas cylinder and a drug-liquid ampoule within the device body.

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On activation, compressed drug-gas is released through the liquid reservoir where perflubron vapor evaporates through an intermediate aerosol stage. The combined gas and vapor mixture is then delivered to a tidally breathing patient at a controlled dosing rate and multi-minute treatment time.

SAMi is developing this portable rescue device to treat severe bronchoconstriction as a first line emergency treatment to complement and enhance the activity of other drugs, particularly when conventional drugs have failed.

This is the first time a therapeutic drug gas combines with a therapeutic drug vapor in a revolutionary portable delivery device to treat respiratory disease.

  • COPD - management
  • Asthma - management
  • Airway management
  • Copyright ©ERS 2015
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First in class, respiratory drug gas & drug vapor delivered in a revolutionary and new portable device
John Dennis, Andy Clark, Ian McAffer, Stefan Dalberg, Francis Green
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4035; DOI: 10.1183/13993003.congress-2015.PA4035

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First in class, respiratory drug gas & drug vapor delivered in a revolutionary and new portable device
John Dennis, Andy Clark, Ian McAffer, Stefan Dalberg, Francis Green
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4035; DOI: 10.1183/13993003.congress-2015.PA4035
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