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Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD

Murat Aydin, Nejat Altintas, Levent Mutlu, Bulent Bilir, Musatfa Oran, Feti Tukubas, Birol Topcu
European Respiratory Journal 2015 46: PA4003; DOI: 10.1183/13993003.congress-2015.PA4003
Murat Aydin
1Biochemistry, Namik Kemal University, Tekirdag, Turkey
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Nejat Altintas
2Pulmonary, Sleep and Critical Care, Namik Kemal University, Tekirdag, Turkey
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Levent Mutlu
1Biochemistry, Namik Kemal University, Tekirdag, Turkey
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Bulent Bilir
3Internal Medicine, Namik Kemal University, Tekirdag, Turkey
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Musatfa Oran
3Internal Medicine, Namik Kemal University, Tekirdag, Turkey
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Feti Tukubas
1Biochemistry, Namik Kemal University, Tekirdag, Turkey
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Birol Topcu
4Biostatistics, Namik Kemal Universuty, Tekirdag, Turkey
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Abstract

Background: Asymmetric dimethylarginine (ADMA) and Nitric oxide (NO) show their mechanism of action reciprocally, thus the balance between these molecules contribute to the tight regulation of airways tone and function. The present study aims to determine the plasma levels of ADMA and NO in patients with chronic obstructive pulmonary disease (COPD) and establish whether their level vary in relation to forced expiratory volume in 1s (FEV1), to assess their role in pathophysiology of COPD.

Materials and Methods: This study consisted of 58 patients with COPD and 30 healthy subjects. Plasma levels of ADMA and NO were measured using enzyme-linked immunosorbent assay and the colorimetric method respectively.

Results: Plasma ADMA levels were significantly higher, however NO levels were lower in patients with COPD compared with healthy controls (p<0.001). Pearson correlation analysis showed that plasma ADMA levels were negatively correlated with NO levels (r=-0.625, p<0.001). Multivariable logistic regression analysis revealed that plasma NO levels were inversely, ADMA levels were directly, associated with the presence of COPD (odds ratio; 0.107 ; P=0.001 and odds ratio; 1.052; p<0.001 respectively). Multiple Linear regression analysis showed that COPD was positively associated with ADMA (p<0.001), however COPD and ADMA were independently and inversely associated with NO (p<0.001 and p = 0.009 respectively). NO levels were decreased, ADMA levels were increased compliant with progression of COPD stages which was measured by post-bronchodilator FEV1

Conclusion: While circulating ADMA is higher, NO is lower in COPD and both show a strong correlation to the degree of airflow limitation.

  • Biomarkers
  • COPD - exacerbations
  • Anti-inflammatory
  • Copyright ©ERS 2015
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Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD
Murat Aydin, Nejat Altintas, Levent Mutlu, Bulent Bilir, Musatfa Oran, Feti Tukubas, Birol Topcu
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4003; DOI: 10.1183/13993003.congress-2015.PA4003

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Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD
Murat Aydin, Nejat Altintas, Levent Mutlu, Bulent Bilir, Musatfa Oran, Feti Tukubas, Birol Topcu
European Respiratory Journal Sep 2015, 46 (suppl 59) PA4003; DOI: 10.1183/13993003.congress-2015.PA4003
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