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LATE-BREAKING ABSTRACT: Phenotypes of COPD in central and Eastern Europe - The POPE study

Vladimir Koblizek, Ruzena Tkacova, Attila Somfay, Branislava Milenkovic, Adam Barczyk, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jan Svancara, Jurij Sorli, Alvis Krams, Marc Miravitlles, Arschang Valipour
European Respiratory Journal 2015 46: PA393; DOI: 10.1183/13993003.congress-2015.PA393
Vladimir Koblizek
1Department of Pneumology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
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Ruzena Tkacova
2Department of Respiratory Medicine, Faculty of Medicine, P.J. Safarik University, Kosice, Slovakia (Slovak Republic)
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Attila Somfay
3Department of Pulmonology, University of Szeged, Deszk, Hungary
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Branislava Milenkovic
4Clinic for Pulmonary Diseases, Clinical Centre of Serbia, Belgrade, Serbia
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Adam Barczyk
5Department of Pneumology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
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Kirill Zykov
6Laboratory of Pulmonology, Moscow State University of Medicine and Dentistry Named after A.I.Evdokimov, Moscow, Russian Federation
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Neven Tudoric
7School of Medicine Zagreb, University Hospital Dubrava, Zagreb, Croatia
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Kosta Kostov
8Pulmonary Diseases Clinic, Military Medical Academy, Sofia, Bulgaria
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Zuzana Zbozinkova
9Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Jan Svancara
9Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic
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Jurij Sorli
10Pulmonary Department, Topolsica Hospital, Topolsica, Slovenia
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Alvis Krams
11Faculty of Medicine, University of Latvia, Riga, Latvia
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Marc Miravitlles
12Pneumology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain
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Arschang Valipour
13Department of Respiratory and Critical Care Medicine, Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner-Spital, Wien, Austria
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Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries. However, data regarding symptom load and clinical phenotypes of patients with COPD in CEE remain largely unknown.

Methods: Participation in the POPE Study (a multicentre, observational cross-sectional survey) was offered to consecutive outpatients with stable COPD in 11 CEE countries if they fulfilled the following criteria: age ≥ 40 years, smoking history ≥ 10 pack-years, post-bronchodilator (BD) FEV1/FVC < 0.7 and absence of COPD exacerbation ≥ 4 weeks.

Results: 3504 patients (66 ± 8.7 yrs, 69% male, post-BD FEV1 53.0 ± 17.5% predicted, Charlson comorbidity index 2.0 ± 1.4, and 1.2 ± 1.6 exacerbations within the last 12 months) were recruited between Apr 2014 and May 2015. The majority of patients were classified as GOLD D or GOLD B (57% and 30.6% of total, respectively). According to predefined phenotypes, 63% of the population were non-exacerbators, 20.5% frequent exacerbators with chronic bronchitis (CB), 9.5% frequent exacerbators without CB, and 7% were patients with asthma-COPD overlap syndrome (ACOS). There were statistically significant differences in symptom load and lung function between these phenotypes.

NON-exacerbatorsACOSFrequent exacerbators without CBFrequent exacerbators with CBp²
CAT total¹15.8 (7.3)¨17.8 (7.8)¯18.2 (7.4)¯22.2 (7.5)°<0.001
Post-bronchodilator FEV1¹55.8 (17.3)¯55.0 (17.6)¯45.5 (15.9)¨47.0 (16.1)¨<0.001
  • ¹Mean and standard deviation. ²One way ANOVA.¯,¨,° indicate homogenous groups (Tukey post hoc test).

  • Conclusion: First results of the POPE study offer insight into symptom load, lung function, and phenotypes of COPD in CEE countries.

    • COPD - diagnosis
    • Comorbidities
    • Spirometry
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    LATE-BREAKING ABSTRACT: Phenotypes of COPD in central and Eastern Europe - The POPE study
    Vladimir Koblizek, Ruzena Tkacova, Attila Somfay, Branislava Milenkovic, Adam Barczyk, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jan Svancara, Jurij Sorli, Alvis Krams, Marc Miravitlles, Arschang Valipour
    European Respiratory Journal Sep 2015, 46 (suppl 59) PA393; DOI: 10.1183/13993003.congress-2015.PA393

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    LATE-BREAKING ABSTRACT: Phenotypes of COPD in central and Eastern Europe - The POPE study
    Vladimir Koblizek, Ruzena Tkacova, Attila Somfay, Branislava Milenkovic, Adam Barczyk, Kirill Zykov, Neven Tudoric, Kosta Kostov, Zuzana Zbozinkova, Jan Svancara, Jurij Sorli, Alvis Krams, Marc Miravitlles, Arschang Valipour
    European Respiratory Journal Sep 2015, 46 (suppl 59) PA393; DOI: 10.1183/13993003.congress-2015.PA393
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