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Aerobic training reverses airway inflammation by increasing the expression of anti-inflammatory cytokines by peribronchial cells but not by skeletal muscle

Ronaldo Aparecido Silva, Francine Maria Almeida, Clarice Rosa Olivo, Beatriz Mangueira Saraiva-Romanholo, Adenir Perini, Milton Arruda Martins, Celso Ricardo Fernandes Carvalho
European Respiratory Journal 2015 46: PA3911; DOI: 10.1183/13993003.congress-2015.PA3911
Ronaldo Aparecido Silva
1Physical Therapy, University of Sao Paulo, Sao Paulo, Brazil
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Francine Maria Almeida
2School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
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Clarice Rosa Olivo
2School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
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Beatriz Mangueira Saraiva-Romanholo
2School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
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Adenir Perini
2School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
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Milton Arruda Martins
2School of Medicine, University of Sao Paulo, Sao Paulo, Brazil
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Celso Ricardo Fernandes Carvalho
1Physical Therapy, University of Sao Paulo, Sao Paulo, Brazil
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Abstract

Aerobic training (AT) increases the expression of IL-10 that reduces airway inflammation; however, the origin of this anti-inflammatory cytokine is poorly known.

Aim: To investigate the expression of IL-10 by lung tissues and skeletal muscle in an asthma model.

Methods: 64 Balb/c mice were divided in groups: Control (CT), AT, Sensitized (OVA) or OVA+AT. Sensitized groups received inhalations (OVA 1-3%;3xwk;30min./session). AT was performed in a treadmill by 15 or 30 days (5xwk;60min./session;50% maximal exercise capacity). Outcomes: IgE and IgG1, bronchoalveolar cell counting as well IL-4, IL-12, TIMP-1, MMP-9, OPN, MCP-1 and anti-inflammatory cytokines (IL-10)(lung tissues). The expression of IL-10 was also quantified in the skeletal muscle (quadriceps).

Results: OVA groups had an increase in the IgE and IgG1, inflammatory cells and expression of all inflammatory cytokines compared with CT and AT groups (p<0.05). The OVA+AT groups had a reduction in the cell migration, IL-4, TIMP-1, MMP-9, OPN, MCP-1, and an increase of IL-10 expressed only by peribronchial cells (p<0.05). Curiously, AT only reduced the IgE, IgG1 and MCP-1 in OVA+AT group after 30 days (p<0.05). The expression of IL-10 by the quadriceps was not changed in either groups.

Conclusion: Aerobic conditioning increases the expression of IL-10 by peribronchial monocytes but not by peripheral muscles.

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  • Anti-inflammatory
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Aerobic training reverses airway inflammation by increasing the expression of anti-inflammatory cytokines by peribronchial cells but not by skeletal muscle
Ronaldo Aparecido Silva, Francine Maria Almeida, Clarice Rosa Olivo, Beatriz Mangueira Saraiva-Romanholo, Adenir Perini, Milton Arruda Martins, Celso Ricardo Fernandes Carvalho
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3911; DOI: 10.1183/13993003.congress-2015.PA3911

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Aerobic training reverses airway inflammation by increasing the expression of anti-inflammatory cytokines by peribronchial cells but not by skeletal muscle
Ronaldo Aparecido Silva, Francine Maria Almeida, Clarice Rosa Olivo, Beatriz Mangueira Saraiva-Romanholo, Adenir Perini, Milton Arruda Martins, Celso Ricardo Fernandes Carvalho
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3911; DOI: 10.1183/13993003.congress-2015.PA3911
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