Abstract
Introduction: Inflammation and physical inactivity are common potential mechanisms for metabolic syndrome (MS) and interstitial lung diseases (ILD). Therefore, we investigated factors determining MS and its frequency in ILDs in the present study.
Method: A total of 64 patients diagnosed with ILD were enrolled in the study. Patients had fibrosis classification (FC) according to Muller method by performing HRCT examinations and total fibrosis score (TFS) was obtained according to fibrosis degree in the whole lung. MS diagnosis was made according to National Cholesterol Education Program (NAEP). Total MS component number was also calculated as MS score. Patients had respiratory function, carbonmonoxide diffusion, and lung volume tests, and arterial blood gaseous analyses were performed.
Results: Of patients, 27 (42%) were diagnosed with MS. In Pearson's correlation test, negative correlations were determined between DLCO% and MS presence (p= 0.005) and MS score (p= 0.04); between TLC% and MS presence (p= 0.02) and MS score (p= 0.01); between physical health score and MS score (p= 0.03). Negative correlations were also determined between physical health score and TFS (p= 0.004), and FC (p= 0.006).
Conclusion: Metabolic disorders in ILD are increased in relationship with parameters showing the disease severity. Further studies are required to determine correlations between these two diseases.
- Copyright ©ERS 2015