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Long-term improvement of pulmonary haemodynamics and exercise capacity in patients with pulmonary hypertension and hypoventilation following NIPPV and influence of NIPPV adherence

Matthias Held, Katharina Schuh, Sabine Karl, Johanna Walthelm, Stefan Baron, Christine Roth, Berthold Jany
European Respiratory Journal 2015 46: PA3766; DOI: 10.1183/13993003.congress-2015.PA3766
Matthias Held
1Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital of the Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Katharina Schuh
1Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital of the Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Sabine Karl
2Insitute of Mathematics, Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Johanna Walthelm
1Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital of the Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Stefan Baron
1Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital of the Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Christine Roth
1Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital of the Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Berthold Jany
1Department of Internal Medicine, Medical Mission Hospital, Academic Teaching Hospital of the Julius Maximilian University Wuerzburg, Wuerzburg, Germany
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Abstract

NIPPV in patients with severe pulmonary hypertension (PH) and hypoventilation improves pulmonary haemodynamics and functional capacity. Long-term observations are lacking.

Aims: To investigate functional long-term outcome and haemodynamics in patients with PH due to hypoventilation and influence of NIPPV adherence.

Methods: Analysis of the two year follow- up in 40 subjects with PH due to hypoventilation using NIPPV more or less than 4 hours per night and 50 % of the treatment time.

Results: NIPPV use > 4h/night and > 50 % (n=28) of the treatment time led to long-term improvement of haemodynamics and functional capacity.

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Table 1

NIPPV use less than 4 hours per night and less than 50% (n=12) of the treatment time improved night-time CO2, but did not improve haemodynamics and exercise capacity.

Conclusion: NIPPV use more than 4 h/night and more than 50 % of the treatment time leads to a significant long-term improvement of haemodynamics and exercise capacity in patients with PH due to hypoventilation.

  • Pulmonary hypertension
  • Non-invasive ventilation - long-term
  • Circulation
  • Copyright ©ERS 2015
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Long-term improvement of pulmonary haemodynamics and exercise capacity in patients with pulmonary hypertension and hypoventilation following NIPPV and influence of NIPPV adherence
Matthias Held, Katharina Schuh, Sabine Karl, Johanna Walthelm, Stefan Baron, Christine Roth, Berthold Jany
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3766; DOI: 10.1183/13993003.congress-2015.PA3766

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Long-term improvement of pulmonary haemodynamics and exercise capacity in patients with pulmonary hypertension and hypoventilation following NIPPV and influence of NIPPV adherence
Matthias Held, Katharina Schuh, Sabine Karl, Johanna Walthelm, Stefan Baron, Christine Roth, Berthold Jany
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3766; DOI: 10.1183/13993003.congress-2015.PA3766
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