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Up-regulation of serum periostin and squamous cell carcinoma antigen levels in respiratory syncytial virus bronchitis of infants

Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Takashi Sekine, Kenji Izuhara, Toshio Katsunuma
European Respiratory Journal 2015 46: PA3627; DOI: 10.1183/13993003.congress-2015.PA3627
Hiroaki Nakamura
1Department of Pediatrics, Toho University Ohashi Medical Center, Meguroku-ku, Tokyo Japan
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Kenichi Akashi
2Department of Pediatrics, The Jikei University Daisan Hospital, Komae-shi, Tokyo Japan
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Masako Watanabe
2Department of Pediatrics, The Jikei University Daisan Hospital, Komae-shi, Tokyo Japan
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Shoichiro Ohta
3Department of Laboratory Medicine, Saga Medical School, Saga-shi, Saga Japan
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Junya Ono
4Shino-Test Corporation, Sagamihara-shi, Kanagawa Japan
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Yoshinori Azuma
4Shino-Test Corporation, Sagamihara-shi, Kanagawa Japan
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Takashi Sekine
1Department of Pediatrics, Toho University Ohashi Medical Center, Meguroku-ku, Tokyo Japan
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Kenji Izuhara
5Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School, Saga-shi, Saga Japan
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Toshio Katsunuma
2Department of Pediatrics, The Jikei University Daisan Hospital, Komae-shi, Tokyo Japan
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Abstract

Background: Respiratory syncytial virus (RSV)-induced bronchiolitis in infancy is a major risk factor for asthma. Recently, periostin and squamous cell carcinoma antigen (SCCA) have been suggested as non-invasive biomarkers of asthma which can be easily assessed for clinical use.

Objective: To clarify the relationship between RSV airway infections with or without an increased risk of asthma and serum periostin/SCCA levels.

Method: We measured the serum levels of periostin, SCCA-1 and -2 in 14 cases of RSV-bronchitis with positive modified asthma predictive index (mAPI (+)), 22 cases of RSV-bronchitis with negative mAPI, 18 cases with food allergy with no respiratory symptoms (positive control) and 18 controls. We also compared the data of RSV-bronchitis between acute and recovery phases.

Results: The levels of periostin, SCCA in acute phases were significantly elevated than in recovery phases. Especially SCCA1 levels were significantly higher than in other groups. However there were no significant differences of biomarkers between the groups with or without mAPI.

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Conclusions: Both periostin and SCCA may play some role in the pathogenesis of RSV-induced acute bronchitis. Further research is required to clarify the role of these molecules in the airway with RSV infection, and usefulness as the biomarker in young children with recurrent wheezing or asthma.

  • Biomarkers
  • Children
  • Bronchiolitis
  • Copyright ©ERS 2015
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Up-regulation of serum periostin and squamous cell carcinoma antigen levels in respiratory syncytial virus bronchitis of infants
Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Takashi Sekine, Kenji Izuhara, Toshio Katsunuma
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3627; DOI: 10.1183/13993003.congress-2015.PA3627

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Up-regulation of serum periostin and squamous cell carcinoma antigen levels in respiratory syncytial virus bronchitis of infants
Hiroaki Nakamura, Kenichi Akashi, Masako Watanabe, Shoichiro Ohta, Junya Ono, Yoshinori Azuma, Takashi Sekine, Kenji Izuhara, Toshio Katsunuma
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3627; DOI: 10.1183/13993003.congress-2015.PA3627
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More in this TOC Section

  • Risk factors for intensive care and respiratory support among infants with bronchiolitis
  • Influence of single nucleotide polymorphisms in post-bronchiolitis wheezing
  • Blood gas analysis in acute bronchiolitis – Who and when?
Show more 7.4 Paediatric Respiratory Infection and Immunology

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