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BioPhysical bronchodilator: A new class of respiratory drug

John Dennis, Richard Leigh, Tamer ElMays, Francis Green
European Respiratory Journal 2015 46: PA3609; DOI: 10.1183/13993003.congress-2015.PA3609
John Dennis
1Division of Drug Inhalation Products, SolAeroMed Inc (SAMi), Calgary, AB Canada
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Richard Leigh
2Section of Respiratory Medicine, University of Calgary and Alberta Health Services, Calgary, AB Canada
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Tamer ElMays
2Section of Respiratory Medicine, University of Calgary and Alberta Health Services, Calgary, AB Canada
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Francis Green
1Division of Drug Inhalation Products, SolAeroMed Inc (SAMi), Calgary, AB Canada
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Abstract

We have discovered a new short acting bronchodilator represents a new class of bronchodilator. The drug, S-1226, is made up of a gas (4-12% CO2 in air) combined with a synthetic lung surfactant, perflubron, delivered as a nebulized mixture of perflubron vapour and perflubron aerosol, within the CO2 gas. We have demonstrated rapid broncho-dilatation via a unique mechanism of action that is neither adrenergic or cholinergic. We suspect the bronchodilator effect of the drug is mediated by epithelial receptors and vagal C-fibres and sustained by the biophysical action of perflubron and its interaction with natural lung surfactants.

Bronchodilation is shown in animal models to be very rapid within 4 seconds and more rapid and prolonged than seen with conventional rapid acting adrenergic (salbutamol) drugs and their analogs in animal models.

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S-1226 has completed Phase I in humans and is currently undergoing Phase II clinical trails to provide proof of concept for safety and efficacy in human asthmatics.

Given it's unique biophysical mechanism, S-1226 represents a new class of bronchodilator drug. S-1226 will have clinical relevance when existing drugs fail.

www.solaeromed.com

  • Airway management
  • Airway smooth muscle
  • Asthma - mechanism
  • Copyright ©ERS 2015
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BioPhysical bronchodilator: A new class of respiratory drug
John Dennis, Richard Leigh, Tamer ElMays, Francis Green
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3609; DOI: 10.1183/13993003.congress-2015.PA3609

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BioPhysical bronchodilator: A new class of respiratory drug
John Dennis, Richard Leigh, Tamer ElMays, Francis Green
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3609; DOI: 10.1183/13993003.congress-2015.PA3609
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