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Chronic effects of air pollution on lung function after lung transplant (SysCLAD)

Valérie Siroux, Meriem Benmerad, Rémy Slama, Karine Botturi, Johanna Claustre, Antoine Roux, Carine Gomez, Romain Kessler, Olivier Brugière, Jean-François Mornex, Sacha Mussot, Marcel Dahan, Véronique Boussaud, Isabelle Danner-Boucher, Claire Dromer, Christiane Knoop, Laure Malherbe, Frederik Meleux, Laurent Nicod, Antoine Magnan, Christophe Pison
European Respiratory Journal 2015 46: PA3405; DOI: 10.1183/13993003.congress-2015.PA3405
Valérie Siroux
1IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Univ. Grenoble Alpes, Grenoble, France
2IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, INSERM, Grenoble, France
3IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, CHU de Grenoble, Grenoble, France
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Meriem Benmerad
1IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Univ. Grenoble Alpes, Grenoble, France
2IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, INSERM, Grenoble, France
3IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, CHU de Grenoble, Grenoble, France
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Rémy Slama
1IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Univ. Grenoble Alpes, Grenoble, France
2IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, INSERM, Grenoble, France
3IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, CHU de Grenoble, Grenoble, France
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Karine Botturi
4Institut du Thorax - INSERM UMR 1087/CNRS UMR 6291, CHU de Nantes, Nantes, France
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Johanna Claustre
5Clinique Universitaire de Pneumologie, CHU de Grenoble, Grenoble, France
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Antoine Roux
6Pneumologie et Transplantation Pulmonaire, Hôpital Foch, Paris, France
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Carine Gomez
7Centre de Compétences des Maladies Pulmonaires Rares et Centre de Compétences de l'Hypertension Artérielle Pulmonaire, Centre Hospitalo-Universitaire, Hopital Nord, Marseille, Marseille, France
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Romain Kessler
8Pôle Pathologie Thoracique, CHU de Strasbourg, Strasbourg, France
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Olivier Brugière
9Unité Pneumologie, Hôpital Bichat - Claude-Bernard AP-HP, Paris, France
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Jean-François Mornex
10Pneumologie - Centre des Maladies Orphelines, Hôpital Louis Pradel, Lyon, France
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Sacha Mussot
11Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardiopulmonaire, Centre Chirurgical Marie Lannelongue, Le Plessis Robinson, France
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Marcel Dahan
12Chirurgie Thoracique, Hôpital Larrey - CHU de Toulouse, Toulouse, France
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Véronique Boussaud
13Chirurgie Cardiovasculaire, Hôpital Européen Georges-Pompidou H.E.G.P. AP-HP, Paris, France
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Isabelle Danner-Boucher
14Service de Pneumologie, CHU de Nantes, Nantes, France
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Claire Dromer
15Unité d'Insuffisance Respiratoire et Transplantation, CHU de Bordeaux, Bordeaux, France
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Christiane Knoop
16Service de Pneumologie, Hôpital Erasme, Brussels, Belgium
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Laure Malherbe
17Direction des Risques Chroniques, INERIS, Verneuil-en-Halatte, France
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Frederik Meleux
17Direction des Risques Chroniques, INERIS, Verneuil-en-Halatte, France
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Laurent Nicod
18Service de Pneumologie, CHU Vaudois, Lausanne, Switzerland
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Antoine Magnan
4Institut du Thorax - INSERM UMR 1087/CNRS UMR 6291, CHU de Nantes, Nantes, France
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Christophe Pison
5Clinique Universitaire de Pneumologie, CHU de Grenoble, Grenoble, France
19Université Grenoble Alpes, Université Grenoble Alpes, Grenoble, France
20INSERM U1055, INSERM, Grenoble, France
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Abstract

We studied the role of chronic exposure to ambiant air pollution on lung function level and evolution in lung transplant patients.

The lung function of 525 lung transplant (LT) patients from the COLT cohort was followed-up. The 12-month average levels of air pollutants (Nitrogen dioxide (NO2), fine particulate matters (PM2.5, PM10) and ozone (O3)) were estimated at the home addresses of each patient. The effect of air pollutant exposure on FEV1 level and change in FEV1 both during the recovery and decline periodes were estimated using mixed linear regression models adjusted on recipient age, sex, smoking (donor and patient), body mass index, donor age, type of LT, underlying disease, sex and HLA mismatch, ischemia time, anti-HLA antibodies, Pseudomonas colonization, CMV infections, immunosuppression induction and acute rejection.

The population included 54% of men and 81% of double LT (mean age 43yrs). The main underlying diseases were cystic fibrosis (40%), emphysema/COPD (34%) and pulmonary arterial hypertension (14%). Mean (sd) individual exposure levels were 15.2 (2.1), 22.1 (3.1), 18.1 (7.3) and 51.7 (8.2) µg/m3 for PM2.5, PM10, NO2 and O3, respectively. NO2 exposure was significantly associated with lower FEV1 levels measured during the recovery period and a non-significant trend was observed in the decline period (estimate (se) = -3.39(1.48) p=0.02 and -1.96(1.47) p=0.18). None of the air pollutants exposure was associated with change in FEV1.

Our results suggest a potential deleterious effect of chronic exposure to NO2 on FEV1 level following LT and did not evidence an effect of air pollution on change in FEV1.

Fundings: EU-FP7 SYSCLAD, Vaincre la Mucoviscidose, Association Gregory Lemarchal.

  • Epidemiology
  • Environment
  • Transplantation
  • Copyright ©ERS 2015
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Chronic effects of air pollution on lung function after lung transplant (SysCLAD)
Valérie Siroux, Meriem Benmerad, Rémy Slama, Karine Botturi, Johanna Claustre, Antoine Roux, Carine Gomez, Romain Kessler, Olivier Brugière, Jean-François Mornex, Sacha Mussot, Marcel Dahan, Véronique Boussaud, Isabelle Danner-Boucher, Claire Dromer, Christiane Knoop, Laure Malherbe, Frederik Meleux, Laurent Nicod, Antoine Magnan, Christophe Pison
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3405; DOI: 10.1183/13993003.congress-2015.PA3405

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Chronic effects of air pollution on lung function after lung transplant (SysCLAD)
Valérie Siroux, Meriem Benmerad, Rémy Slama, Karine Botturi, Johanna Claustre, Antoine Roux, Carine Gomez, Romain Kessler, Olivier Brugière, Jean-François Mornex, Sacha Mussot, Marcel Dahan, Véronique Boussaud, Isabelle Danner-Boucher, Claire Dromer, Christiane Knoop, Laure Malherbe, Frederik Meleux, Laurent Nicod, Antoine Magnan, Christophe Pison
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3405; DOI: 10.1183/13993003.congress-2015.PA3405
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