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The effect of frequent use of hypnotics on HRQOL in patients receiving LTOT and/or long-term NIV

Tomomasa Tsuboi, Toru Oga, Takefumi Saito, Shohei Takada, Shuichi Yano, Tetsuro Ohdaira, Yoshiro Mochizuki, Toru Yamanaka, Masahiro Abe, Kensuke Sumi, Kazuo Chin
European Respiratory Journal 2015 46: PA3059; DOI: 10.1183/13993003.congress-2015.PA3059
Tomomasa Tsuboi
1Respiratory Medicine, National Hospital Organization Minami Kyoto Hospital, Joyo, Kyoto Japan
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Toru Oga
2Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
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Takefumi Saito
3Respiratory Medicine, National Hospital Organization Ibarakihigashi National Hospital, Naka, Ibaraki Japan
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Shohei Takada
4Respiratory Medicine, National Hospital Organization Fukuoka Higashi Medical Center, Koga, Fukuoka Japan
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Shuichi Yano
5Respiratory Medicine, National Hospital Organization Matsue Medical Center, Matsue, Shimane Japan
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Tetsuro Ohdaira
6Respiratory Medicine, National Hospital Organization Nishi-Niigata Chuo National Hospital, Niigata, Japan
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Yoshiro Mochizuki
7Respiratory Medicine, National Hospital Organization Himeji Medical Center, Himeji, Hyogo Japan
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Toru Yamanaka
8Respiratory Medicine, National Hospital Organization Kumamoto Minami Hospital, Uki, Kumamoto Japan
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Masahiro Abe
9Respiratory Medicine, National Hospital Organization Ehime Medical Center, Toon, Ehime Japan
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Kensuke Sumi
1Respiratory Medicine, National Hospital Organization Minami Kyoto Hospital, Joyo, Kyoto Japan
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Kazuo Chin
2Respiratory Care and Sleep Control Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan
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Abstract

Background and Aims: Most hypnotics are avoided in patients with severe chronic respiratory failure. Those patients however complain insomnia and need hypnotics. To clarify the effect of hypnotics on those patients' HRQOL, clinical stability, and prognosis are necessary.

Methods: We have started a 5-years prospective, multi-center, observational study including 355 patients receiving LTOT or/and long-term NIV. Patients' characteristics, laboratory data including ABGs, usage of hypnotics, and their HRQOL (SRI, HAD, PSQI, AIS, MRC, ESS, and categorized LSEQ) were examined.

Results: 117 patients took some hypnotics frequently (more than ten times per month). There were no differences in patients' characteristics and laboratory data including ABGs between those using hypnotics and the other patients. Their SRI total score was lower (p<0.001). They were more anxious (p=0.002), and more depressed (p<0.0001). Their sleep was more disordered (PSQI total score, p<0.0001; AIS, p<0.0001). Their daytime perceived dyspnea was similar (MRC, p=0.89). Their daytime sleepiness was less (ESS, p=0.004). During the night with hypnotics, getting to sleep was easier and quicker, sleep was more restful and fewer wakeful, awakening was easier, and feeling on waking was more alert (categorized LSEQ) in patients taking hypnotics frequently.

Conclusions: The rate of patients frequently taking hypnotics was more than 30%. Their HRQOL was significantly lower than the other patients. However, their exertional dyspnea was same, and their sleepiness was less. Hypnotics could improve their sleep. Long-term prospective study has started to elucidate the effect of frequent use of hypnotics.

  • Oxygen therapy
  • Non-invasive ventilation - long-term
  • Quality of life
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The effect of frequent use of hypnotics on HRQOL in patients receiving LTOT and/or long-term NIV
Tomomasa Tsuboi, Toru Oga, Takefumi Saito, Shohei Takada, Shuichi Yano, Tetsuro Ohdaira, Yoshiro Mochizuki, Toru Yamanaka, Masahiro Abe, Kensuke Sumi, Kazuo Chin
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3059; DOI: 10.1183/13993003.congress-2015.PA3059

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The effect of frequent use of hypnotics on HRQOL in patients receiving LTOT and/or long-term NIV
Tomomasa Tsuboi, Toru Oga, Takefumi Saito, Shohei Takada, Shuichi Yano, Tetsuro Ohdaira, Yoshiro Mochizuki, Toru Yamanaka, Masahiro Abe, Kensuke Sumi, Kazuo Chin
European Respiratory Journal Sep 2015, 46 (suppl 59) PA3059; DOI: 10.1183/13993003.congress-2015.PA3059
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