Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

The value of immunological methods in the diagnosis of tuberculosis in patients with HIV

Vera Manina, Anna Starshinova, Alexandr Panteleev, Viacheslav Zhuravlev, Maria Pavlova, Nadezda Sapozhnikova, Piotr Yablonskii, Alena Vasilyeva
European Respiratory Journal 2015 46: PA2981; DOI: 10.1183/13993003.congress-2015.PA2981
Vera Manina
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anna Starshinova
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alexandr Panteleev
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
3o, Saint-Petersburg, Russian Federation
4Department of Socially Significant Infections, St. Petersburg State Medical University, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Viacheslav Zhuravlev
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria Pavlova
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nadezda Sapozhnikova
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Piotr Yablonskii
1Phthisiopulmonology Department, St-Petersburg Research Institute of Phthisiopulmonology, Saint-Petersburg, Russian Federation
2Department of Medicine, St. Petersburg State University, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alena Vasilyeva
5Laboratory of Immunology, Research Institute of Epidemiology and Microbiology, Saint-Petersburg, Russian Federation
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
Loading

Abstract

Objective: to determine and compare parameters of diagnostic value of immunological tests in the diagnosis of tuberculosis in patients with HIV infection.

Materials and methods: During 2013-2014 years' cohort study was conducted. Were examined 88 patients with HIV infection and healthy people (control group – n=18). Diagnostic complex included: QuantiFERON®-TB Gold (QFT), TB.SPOT, X-ray, sputum smear examination, cultural and PCR methods. Patients were divided into two groups: I- HIV(n=41) and II -HIV + TB(n = 43).

Results: Data of immunological study are presented in table.

TB.SPOT(n/%)QFT(n/%)
PatientsPos.Doub.Neg.Pos.Doub.Neg.
I group (41)26.8/114.9/268.3*/2829.2/12070.7**/29
II group (43)83.8*/366.9/39.3/479.1**/344.6/216.3/
control group (18)22.2/25.5/183.3*** /1516.7/35.5/177.8*** /14
  • * p<0,01 compared I and II ** p<0,001 compared I and II ***p<0,001 compared II and III

  • Results of immunological tests in groups

    Significant results were obtained in group II with a positive test result for both TB.SPOT, and QFT. RR for positive result of TB.SPOT (RR = 3.3) in group II was twice higher than QFT (RR = 2.5). In group I, RR of positive result for TB.SPOT (RR = 0,3) was comparable with QFT (RR = 0,2). Indicators of the diagnostic significance of TB.SPOT (Se = 90.0%, Sp = 88.2%, DV = 89.1%) and QFT (Se = 82.9%, Sp = 82.4%, DV= 82.7%) were comparable.

    Conclusions: Results of TB.SPOT was slightly higher than QFT in the diagnosis of tuberculosis infection in patients with HIV. Risk factor for a positive result TB.SPOT two times higher than the figure QFT, which significantly increases the ability to detect latent TB infection in patients with HIV.

    • IGRA (Interferon gamma)
    • Immunology
    • Tuberculosis - diagnosis
    • Copyright ©ERS 2015
    Previous
    Back to top
    Vol 46 Issue suppl 59 Table of Contents
    • Table of Contents
    • Index by author
    Email

    Thank you for your interest in spreading the word on European Respiratory Society .

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    The value of immunological methods in the diagnosis of tuberculosis in patients with HIV
    (Your Name) has sent you a message from European Respiratory Society
    (Your Name) thought you would like to see the European Respiratory Society web site.
    CAPTCHA
    This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
    Citation Tools
    The value of immunological methods in the diagnosis of tuberculosis in patients with HIV
    Vera Manina, Anna Starshinova, Alexandr Panteleev, Viacheslav Zhuravlev, Maria Pavlova, Nadezda Sapozhnikova, Piotr Yablonskii, Alena Vasilyeva
    European Respiratory Journal Sep 2015, 46 (suppl 59) PA2981; DOI: 10.1183/13993003.congress-2015.PA2981

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero

    Share
    The value of immunological methods in the diagnosis of tuberculosis in patients with HIV
    Vera Manina, Anna Starshinova, Alexandr Panteleev, Viacheslav Zhuravlev, Maria Pavlova, Nadezda Sapozhnikova, Piotr Yablonskii, Alena Vasilyeva
    European Respiratory Journal Sep 2015, 46 (suppl 59) PA2981; DOI: 10.1183/13993003.congress-2015.PA2981
    del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

    Jump To

    • Article
    • Figures & Data
    • Info & Metrics
    • Tweet Widget
    • Facebook Like
    • Google Plus One

    More in this TOC Section

    • Diagnostic accuracy of pleural fluid adenosine deaminase in patients with tuberculous pleural effusion while keeping pleural biopsy as a gold standard
    • Features of different M.tuberculosis strains that were isolated from MDR-TB patients in Kharkiv, Ukraine
    • GENE-XPERT gives early diagnosis in early tuberculosis
    Show more 10.2 Tuberculosis

    Related Articles

    Navigate

    • Home
    • Current issue
    • Archive

    About the ERJ

    • Journal information
    • Editorial board
    • Reviewers
    • Press
    • Permissions and reprints
    • Advertising

    The European Respiratory Society

    • Society home
    • myERS
    • Privacy policy
    • Accessibility

    ERS publications

    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS books online
    • ERS Bookshop

    Help

    • Feedback

    For authors

    • Instructions for authors
    • Publication ethics and malpractice
    • Submit a manuscript

    For readers

    • Alerts
    • Subjects
    • Podcasts
    • RSS

    Subscriptions

    • Accessing the ERS publications

    Contact us

    European Respiratory Society
    442 Glossop Road
    Sheffield S10 2PX
    United Kingdom
    Tel: +44 114 2672860
    Email: journals@ersnet.org

    ISSN

    Print ISSN:  0903-1936
    Online ISSN: 1399-3003

    Copyright © 2023 by the European Respiratory Society