Abstract
Introduction: Resistant forms of TB are and will be always the threat. There is a need to control during and after treatment period, to determine the possible resistant cases. Serbia use TB drugs from GLC since 2009.
Aim: To analyse situation with resistent TB patients (mono,poli,MDR/XDR-TB) in Vojvodina province (northern part in Serbia, 2 million population).
Method: Retrospective study included 47 pateints during 2000-2014. Data got from the hospital and microbiological forms (Institute for pulmonary dieseases of Vojvodina). Sensitivity test findings from National reference center in Belgrade (Serbia) and Supranational reference centar in Borstel (Germany).
Results: Study included 47 patients, mostly males (n=39, 82.9 %). Most of monoresistants were to H (8/13), most of poliresistants were to HS (4/7). MDR-TB in 23 patients (48.9%). In period 2005-2014 -11/23 patients MDR TB (2005-beginning of implementation of DOTS in Serbia). The primary MDR had 3 patients (living/working in former Soviet countries). Rest of them had several relapses (max. 3 in two patients) or disrupted treatment (max. 4 disrupted in two patients). XDR-TB had 4 (8.5%) patients; all had chronic psychiatry disease (schizophrenia). During this period 8 patients died (all 4 with XDR, 3 MDR, 1 with poli). Present situation in Vojvodina Jan. 2015: 4 cases of MDR (2 are in psihiatric center), none XDR.
Conclusions: There must be continuing screening among patients who have TB and chronic comorbidities, people in prisons and who are living /working in former Soviet countries. WHO guidelines are crucial for treatment and control MDR/XDR-TB, even there is decreasing TB incidence in world.
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