Abstract
The proportion of drug-resistant TB cases is a useful indicator for assessing the performance of a TB control programme. The aim of this study is thus to Detection of prevalence and trend resistance and evaluate risk factors for any drug-resistant TB and MDR-TB in Istanbul, Turkey between 2005-2012.
Methods: This study is a retrospective cohort study involving tuberculosis patients receiving treatment between 1st January 2005 and 31st December 2012 carried out at TB dispensaries in Istanbul. Patients who were not tested culture methods (n=20.365), patients who had culture negative (n=5413). In patients who had culture positive (n=19.775), patients had not tested DST (n=2654). Patients who were tested with TB drug susceptibility were analyzed (n=17.121).
Results: Rating TB population tested for drug susceptibility was seen increasing (24.0% vs 47.6 %). Rating any drug resistance; in total cases (11.7% vs 15.9%), in previous treated cases (25.6% vs 34.9%), Rating MDR; in total cases (5.6% vs 6.2%), in previous treated cases (16.4 % vs 23.1%) was increasing. Any drug resistance was significantly high (AOR (1.43 (1.18–1.75)) in 2012 according to 2005. In other country birth, Any drug resistance (AOR (2.21 (1.69–2.89)), MDR (AOR (3.36 (2.41-4.70)) was found significantly high. In previous treated history, Any drug resistance (AOR (3.18 (2.85-3.54)), MDR-TB (AOR (6.70 (5.82-7.72)) was found significant in previous treated history.
Conclusion: Rating TB population tested for drug susceptibility is increasing by years. Information remains incomplete in the world. Other country birth and previous treatment history should be more closely follow up.
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