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LATE-BREAKING ABSTRACT: Differences in S. pneumoniae serotypes distribution causing CAP in hospitalized adults in Spain according to comorbidities by a new urinary antigen detection (UAD) test. The CAPA study

Rosario Menéndez, Antoni Torres, Pedro Pablo España, Emilio Pérez-Trallero, José Luis López Hontangas, Francesc Marco, Ana Patricia Martínez de la Fuente, José María Marimón, Alexandra Gimeno, Catia Cilloniz, Ane Uranga, María Ercibengoa, César Balseiro, Cristina Méndez, Isabel Cifuentes
European Respiratory Journal 2015 46: PA2581; DOI: 10.1183/13993003.congress-2015.PA2581
Rosario Menéndez
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Antoni Torres
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Pedro Pablo España
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Emilio Pérez-Trallero
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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José Luis López Hontangas
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Francesc Marco
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Ana Patricia Martínez de la Fuente
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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José María Marimón
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Alexandra Gimeno
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Catia Cilloniz
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Ane Uranga
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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María Ercibengoa
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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César Balseiro
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Cristina Méndez
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Isabel Cifuentes
1Pneumology, Hospital Universitario y Politécnico La Fe, Valencia, Spain
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Abstract

Background and objective: The presence of underlying conditions increases the risk of CAP. The 13-valent pneumococcal conjugate vaccine (PCV13) has demonstrated efficacy in the prevention of pneumococcal pneumonia and invasive pneumococcal disease in adults. In order to assess the burden of CAP, including non-bacteremic CAP, due to PCV13 serotypes (St), we explored differences in the distribution of PCV13 St in immunocompetent patients >18 years hospitalized in 3 Spanish hospitals (November 2011-June 2014) by presence of underlying conditions.

Methods: In subjects hospitalized with chest X-ray confirmed CAP, microbiological confirmation was sought by the novel UAD assay (Pfizer's PCV13 serotype specific urinary antigen detection test), BinaxNOW & conventional cultures. Serotyping of pneumococcal isolates was accomplished in a central laboratory using Quellung reaction.

Results: S. pneumoniae CAP was confirmed in 351 (29.8%) of 1179 included patients. Underlying conditions and/or risk habits were present in 87.4% of patients (mean age 67.7±17.9). Below table shows PCV13 St distribution in CAP by presence of specific underlying conditions according to UAD test results.

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Conclusion: Among at risk adults with chronic diseases, more than 50% of pneumococcal CAP cases were due to PCV13 serotypes.

  • Pneumonia
  • Epidemiology
  • Vaccination
  • Copyright ©ERS 2015
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LATE-BREAKING ABSTRACT: Differences in S. pneumoniae serotypes distribution causing CAP in hospitalized adults in Spain according to comorbidities by a new urinary antigen detection (UAD) test. The CAPA study
Rosario Menéndez, Antoni Torres, Pedro Pablo España, Emilio Pérez-Trallero, José Luis López Hontangas, Francesc Marco, Ana Patricia Martínez de la Fuente, José María Marimón, Alexandra Gimeno, Catia Cilloniz, Ane Uranga, María Ercibengoa, César Balseiro, Cristina Méndez, Isabel Cifuentes
European Respiratory Journal Sep 2015, 46 (suppl 59) PA2581; DOI: 10.1183/13993003.congress-2015.PA2581

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LATE-BREAKING ABSTRACT: Differences in S. pneumoniae serotypes distribution causing CAP in hospitalized adults in Spain according to comorbidities by a new urinary antigen detection (UAD) test. The CAPA study
Rosario Menéndez, Antoni Torres, Pedro Pablo España, Emilio Pérez-Trallero, José Luis López Hontangas, Francesc Marco, Ana Patricia Martínez de la Fuente, José María Marimón, Alexandra Gimeno, Catia Cilloniz, Ane Uranga, María Ercibengoa, César Balseiro, Cristina Méndez, Isabel Cifuentes
European Respiratory Journal Sep 2015, 46 (suppl 59) PA2581; DOI: 10.1183/13993003.congress-2015.PA2581
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