Abstract
The multi-drug resistant pulmonary tuberculosis (PT) increased in recent years. Prognostic factors and functional status in estimating risk of lung resection for patients with PT is not definitely.
Aim of study was to elucidate the prognostic factors for pneumonectomy in patients with PT.
Methods: We analysed preoperative clinical and pulmonary function status and 30-day period after pneumonectomy in 56 patients with PT. All patients were performed Spirometry, Bodyplethysmography, measurement of Diffusion capacity for carbon monoxide (DLCO) on MasterScreen Body Diffusion (VIASYS Healthcare), Computed tomography on AQUILION PRIME (TOSHIBA) before surgery. We used descriptive statistics and Mann-Whitney U Test. Data are presented as mean±SD. Statistical significance was determined at a p-value <0,05.
Results: There was not registered 30-day postoperative mortality in all surveyed patients. The complications following surgery were in 13 patients. Those patients were older (45,2±12,4 years vs 36,5±10,8, p<0,05), their age of smoking was bigger (18,1±13,6 pack-years vs 10,3±10,1, p<0,05) and Charlson Comorbidity Index was bigger too (0,77±0,81 vs 1,3±0,85). COPD was the most frequent comorbidity in patients with complications (38%). At the group with complications we registered more often mixed ventilation disorders (31% vs 19%), bronchospasm (54% vs 12%) and severe decrease of DLCO (46% vs 28%).
Conclusion: The possible poor prognostic factors were age after 45, COPD as comorbidity, mixed ventilation disorders, bronchospasm and significant decrease of diffusion capacity. The meaning of pulmonary function testing as criterion of functional operability for patients with PT demands the further analysis.
- Copyright ©ERS 2015
