Abstract
Background: Nocturia (two or more urinations per night) is a common symptom in obstructive sleep apnea syndrom (OSAS). Increased intra-abdominal pressure, higher secretion of atrial natriuretic peptide and arousals are responsible for nocturnal urination.
Aims and methods: The aim of this study was to evaluate prevalence of nocturia in confirmed OSA.
Results: We studied 100 (47 males and 53 females) consecutive confirmed OSA patients (mean: age – 50.5±13.7 years, AHI – 33.4±25.5, BMI – 34.5±6.5). Cardiovascular complications were frequent in studied group - arterial hypertension (37%), coronary artery disease (25%), heart failure (9%) and diabetes (31%). To assess relations between nocturia and age, sex, AHI, overnight saturation, BMI, daytime sleepiness we divided subjects in two groups: 1st with nocturia (61 pts; 61% - group N) and 2nd (without nocturia – 39 pts; 39% - group WN). Characteristics of both groups in table below:
| Variable | Group WN | Group N | P |
| Sexe | M- 57.4%; F - 42.7% | M-42.6%; F- 57,3% | NS |
| Age (years) | 47.1 ±15,5 | 52.7±12 | p=0,046 |
| AHI (n/h) | 28.8±21.1 | 34,1 ±26.7 | P=0,031 |
| BMI (kg/m2) | 31,7±5.6 | 36.8±5.7 | p=0.001 |
| SaO2 mean (%) | 91.3±2.7 | 89.7±3.5 | p=0.02 |
| SaO2 min. (%) | 86.1±6.5 | 79.3 ±12.4 | p=0.003 |
| Epworth sleepiness score (points) | 11.3 ±5.5 | 12.8±3.6 | NS |
A univariate analysis revealed a significant non parametric correlation between nocturia and AHI ( p=0.02). Prevalence of nocturia in severe OSAS is higher than in mild OSAS (82 % vs 2%, p=0.001).
Conclusion: Nocturia is frequent in males and females with OSAS. Nocturnal urination is related to severity of OSAS.
- Copyright ©ERS 2015
