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Impact of CPAP treatment on pro-BNP in obstructive sleep apnea syndrome

Sameh M'Saad, Malek Grati, Rim Marrakich, Rania Gargouri, Samy Kammoun, Kamel Jamoussi
European Respiratory Journal 2015 46: PA2328; DOI: 10.1183/13993003.congress-2015.PA2328
Sameh M'Saad
1Respiratory Department, Hedi Chaker Hospital. Faculty of Medicine, Sfax, Tunisia
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Malek Grati
2Department of Biochemistry, Hedi Chaker Hospital. Faculty of Medicine, Sfax, Tunisia
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Rim Marrakich
2Department of Biochemistry, Hedi Chaker Hospital. Faculty of Medicine, Sfax, Tunisia
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Rania Gargouri
1Respiratory Department, Hedi Chaker Hospital. Faculty of Medicine, Sfax, Tunisia
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Samy Kammoun
1Respiratory Department, Hedi Chaker Hospital. Faculty of Medicine, Sfax, Tunisia
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Kamel Jamoussi
2Department of Biochemistry, Hedi Chaker Hospital. Faculty of Medicine, Sfax, Tunisia
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Abstract

Background: Obstructive sleep apnea (OSA) patients have increased cardiovascular morbidity and mortality. The cardiovascular markers associated with OSA are currently not defined.

Objective: The aim of this study is to evaluate whether repeated apneas and hypoxia influence the levels of pro-brain natriuretic peptide (BNP) in OSAS patients and if these effects could be reversed by treatment.

Patients and Methods: A prospective study in 61 consecutive patients with suspected sleep disordered breathing referred to our sleep laboratory was conducted. OSAS was confirmed by polygraphy (PG). Serum pro-BNP was measured prior to and after 3 months of CPAP therapy.

Results: Low or high levelsof NT-pro-BNP were not associated with apnea-hypopnea indexand other sleep related indices (p=0.6).A statistically significant difference was observed between basal and three-month pro-BNP levels in hypertensive (39 +/-9.9 pg/ml to 28 +/-7.4 pg/ml, p=0.03) and normotensive (25.2+/-6.8 pg/ml to 20 +/-5.3 pg/ml, p=0.025) patients with OSAS.

Conclusions: CPAP therapy may improve cardiovascular comorbidity and co-mortality in OSAS and sleep disordered breathing, in general.

  • Apnoea / Hypopnea
  • Biomarkers
  • Sleep studies
  • Copyright ©ERS 2015
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Impact of CPAP treatment on pro-BNP in obstructive sleep apnea syndrome
Sameh M'Saad, Malek Grati, Rim Marrakich, Rania Gargouri, Samy Kammoun, Kamel Jamoussi
European Respiratory Journal Sep 2015, 46 (suppl 59) PA2328; DOI: 10.1183/13993003.congress-2015.PA2328

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Impact of CPAP treatment on pro-BNP in obstructive sleep apnea syndrome
Sameh M'Saad, Malek Grati, Rim Marrakich, Rania Gargouri, Samy Kammoun, Kamel Jamoussi
European Respiratory Journal Sep 2015, 46 (suppl 59) PA2328; DOI: 10.1183/13993003.congress-2015.PA2328
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More in this TOC Section

  • Comparison of peri-pharyngeal muscle recruitment during upper airway obstruction in patients with OSA and healthy subjects during wakefulness and sleep
  • Telemetrically triggered interventions in the first month of cpap treatment - A prospective, randomized controlled intervention trial in patients with a new diagnosis of obstructive sleep apnea syndrome
  • Home telemonitoring and adjustement of CPAP settings in patients with sleep apnea
Show more 4.2 Sleep and Control of Breathing

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