Abstract
Objective: To evaluate the efficacy of FEV6as surrogate for FVC in the diagnosis of COPD, and to determine the fixed cut-off point of FEV1/FEV6 which can be used as an alternative for FEV1/FVCMethods Spirometry measurements were performed in 128 COPD patients, FEV1,FEV6,FVc, FEV1% pred, FVC% pred FEV1/FVC,and FEV1/FEV6 were measured and analyzed. FEV1/FVC < 70% was used as the "gold stadard".Severity of obstruction was based on FEV1% pred.
Results: There were 51% participants with FEV1/FVC>=70%,49% with FEV1/FVC <70%.Linear correlation was revealed between FEV1/FVC and FEV1/FEV6 with the value close to 1.From ROC curve analysis, the FEV1/FVE6<71.14% was the best cut-off point corresponding to FEV1/FVC <70%.
Conclusion: These reseach results suggest that FEV1/FEV6 is a valid alternative to FEV1/FVC for spirometric diagnosis of airway obstruction.
- Copyright ©ERS 2015
