Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Oxidative stress is associated with muscle wasting after aortic surgery

Richard Paul, Mattia Gomarasca, Eleonora D'Angelo, Lisa Barbaro, Gregory Quinlan, Mark Griffiths
European Respiratory Journal 2015 46: PA2149; DOI: 10.1183/13993003.congress-2015.PA2149
Richard Paul
1Adult Intensive Care Unit, Royal Brompton Hospital, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mattia Gomarasca
1Adult Intensive Care Unit, Royal Brompton Hospital, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Eleonora D'Angelo
1Adult Intensive Care Unit, Royal Brompton Hospital, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa Barbaro
2Faculty of Medicine, National Heart and Lung Institute, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory Quinlan
2Faculty of Medicine, National Heart and Lung Institute, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Griffiths
1Adult Intensive Care Unit, Royal Brompton Hospital, London, United Kingdom
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

ICU Acquired Paresis (ICUAP) leads to prolonged recovery and reduced quality of life in survivors of ICU. Patients undergoing aortic surgery experience an ischaemia-reperfusion (IR) injury mimicking the SIRS/sepsis response. 50% of patients demonstrate muscle loss post-operatively, representing a homogenous cohort to study the pathogenesis of ICUAP.

Objectives:

  1. To investigate if oxidative stress in these patients correlated with loss of muscle bulk in the post-operative period

  2. To assess a new system for measuring oxidative stress (RedoxSysTM) that measures static (sORP) and capacity (cORP) oxidation-reduction potential and compare it to conventional markers

Methods: 11 Patients undergoing major aortic surgery were grouped post-hoc into either wasters (n=6) or non-wasters (n=5) based on serial rectus femoris ultrasound measurements (≤ or ≥ 10% muscle bulk loss). Serum samples (day 0,1,3 & 7) post-operatively were tested for sORP, cORP and a marker of ischaemia (xanthine) by HPLC.

Results: 24-hours following surgery, sORP increased (17.2% vs 4.3%, p =0.03) and cORP decreased (46.7% vs 29.6%, p = 0.004) significantly more in wasters compared to non-wasters. Both returned to baseline by the 7th post-operative day in non-wasters but cORP remained persistently reduced in wasters (32.9% vs 12.0%, p=0.04). Serum xanthine was persistently raised in wasters compared to non-wasters across all time points.

Conclusion: Oxidative stress following aortic surgery was persistently raised in patients with muscle wasting compared to those without. The RedoxSYS system agreed with another surrogate of oxidative stress. Further investigation of its utility in monitoring the degree of oxidative stress is warranted.

  • Critically ill patients
  • Skeletal muscle
  • Intensive care
  • Copyright ©ERS 2015
Previous
Back to top
Vol 46 Issue suppl 59 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Oxidative stress is associated with muscle wasting after aortic surgery
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Oxidative stress is associated with muscle wasting after aortic surgery
Richard Paul, Mattia Gomarasca, Eleonora D'Angelo, Lisa Barbaro, Gregory Quinlan, Mark Griffiths
European Respiratory Journal Sep 2015, 46 (suppl 59) PA2149; DOI: 10.1183/13993003.congress-2015.PA2149

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Oxidative stress is associated with muscle wasting after aortic surgery
Richard Paul, Mattia Gomarasca, Eleonora D'Angelo, Lisa Barbaro, Gregory Quinlan, Mark Griffiths
European Respiratory Journal Sep 2015, 46 (suppl 59) PA2149; DOI: 10.1183/13993003.congress-2015.PA2149
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • The negative effect of initial high-dose methylprednisolone and tapering regimen for acute respiratory distress syndrome: A retrospective propensity matched cohort study
  • Acute respiratory failure in progressive neurological diseases: What is important for intensive care unit and long-term survival?
  • Is airway driving pressure a good predictor of lung stress during mechanical ventilation for ARDS?
Show more 2.1 Acute Critical Care

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society