Abstract
Background: Cystic Fibrosis (CF)patients with severe disease can have reduced exercise tolerance usually attributed to ventilatory factors and aerobic capacity.Recently,it was shown that Stroke Volume (SV) may be reduced in CF in relation to airways obstruction.
Aim of the study: was to evaluate the SV at rest and during exercise in relation to airways obstruction in FC patients compared to control group.
Material and methods: We enrolled 20 CF patients,mean age 14.2 ±2.1(range 12-18)divided in two Groups:GrA=FEV1>80% of predicted (n=11);GrB= FEV1<80% of predicted (n=9) and 20 healthy controls(GrC), mean age 15.6±1.6(range 13-18).They underwent cardiopulmonary exercise testing (CPET), spirometry and echocardiography. During CPET,we measured SV,SVI,CO,CI and SVR in all subjects, using an impedance-cardiography device.
Results: figures 1 and 2 show the mean values of cardiac and respiratory parameters measured.
Conclusion: we found lower SV and CO at rest and an attenuated increment of those parameters during exercise in GrB compared to GrA and GrC.Alterated conditions in GrB could be due to higher values of SVR, reduced physical activity and worse nutritional status.
- Copyright ©ERS 2015
