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Acute viral respiratory tract infections and wheezing at follow-up in children < 3 years

Antonella Frassanito, Ambra Nicolai, Raffaella Nenna, Giulia Cangiano, Stefano Papasso, Enrica Mancino, Stefania Sirianni, Giulia Faiola, Alessandra Pierangeli, Carolina Scagnolari, Corrado Moretti, Fabio Midulla
European Respiratory Journal 2015 46: PA1319; DOI: 10.1183/13993003.congress-2015.PA1319
Antonella Frassanito
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Ambra Nicolai
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Raffaella Nenna
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Giulia Cangiano
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Stefano Papasso
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Enrica Mancino
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Stefania Sirianni
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Giulia Faiola
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Alessandra Pierangeli
2Virology Laboratory Molecular Medicine, "Sapienza" University of Rome, Rome, Italy
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Carolina Scagnolari
2Virology Laboratory Molecular Medicine, "Sapienza" University of Rome, Rome, Italy
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Corrado Moretti
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Fabio Midulla
1Department of Paediatrics, "Sapienza" University of Rome, Rome, Italy
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Abstract

Background: Acute viral respiratory tract infections (ARTIs) are the most frequent diseases in children.

Aim: To analyze risk factors for ARTIs, to evaluate clinical differences among children with different viral respiratory infection and to study virological risk factors for recurrent wheezing at 3 years follow-up.

Methods: We studied 273 children (median age 2.9 months, 167M) hospitalized at the Paediatric Emergency Department, “Sapienza” University of Rome (Oct 2009-May 2014) with ARTIs (148 had RSV infection, 67 hRV, 13 hMPV, 10 hBoV, 29 co-infections and 6 other viruses) and 101 control children. We performed a follow-up after 3 years.

Results: Risk factors for ARTIs were the presence of siblings (p<0.001), parent's asthma (p=0.008) and smoking cohabitants (p=0.002). RSV was the main cause of bronchiolitis (118) followed by wheezing bronchitis (23), pneumonia (5), URTIs (2). HRV caused 29 bronchiolitis, 22 wheezing bronchitis, 11 pneumonia, 5 URTIs. HBoV caused 3 bronchiolitis, 5 wheezing bronchitis, 1 pneumonia and URTIs. HMPV caused 8 bronchiolitis, 3 URTIs, 1 pneumonia and wheezing bronchitis. No differences were found according to the virus etiology in clinical severity score and other clinical symptoms. 77.6% of eligible families answered to the follow-up interview. RSV infants had wheezing more frequently than hRV infants (p=0.04).

Conclusions: Environmental and genetic factors contribute to ARTIs. Clinical entities depend on viral etiology. RSV is the virus. RSV infants had more often long lasting sequelae.

  • Viruses
  • Wheezing
  • Bronchiolitis
  • Copyright ©ERS 2015
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Acute viral respiratory tract infections and wheezing at follow-up in children < 3 years
Antonella Frassanito, Ambra Nicolai, Raffaella Nenna, Giulia Cangiano, Stefano Papasso, Enrica Mancino, Stefania Sirianni, Giulia Faiola, Alessandra Pierangeli, Carolina Scagnolari, Corrado Moretti, Fabio Midulla
European Respiratory Journal Sep 2015, 46 (suppl 59) PA1319; DOI: 10.1183/13993003.congress-2015.PA1319

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Acute viral respiratory tract infections and wheezing at follow-up in children < 3 years
Antonella Frassanito, Ambra Nicolai, Raffaella Nenna, Giulia Cangiano, Stefano Papasso, Enrica Mancino, Stefania Sirianni, Giulia Faiola, Alessandra Pierangeli, Carolina Scagnolari, Corrado Moretti, Fabio Midulla
European Respiratory Journal Sep 2015, 46 (suppl 59) PA1319; DOI: 10.1183/13993003.congress-2015.PA1319
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