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Equipment specific reference ranges for the raised volume technique (RVRTC) in infants: A multi-centre collaboration

Sooky Lum, Vassiliki Bountziouka, Angela Wade, Jane Kirkby, Antonio Moreno-Galdo, Olaia SardonPrado, Joerg Mattes, Luis Miguel Borrego, Joanne Miles, Janet Stocks
European Respiratory Journal 2015 46: PA1261; DOI: 10.1183/13993003.congress-2015.PA1261
Sooky Lum
1Respiratory, Critical Care & Anaesthesia Section, UCL, Institute of Child Health, London, United Kingdom
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Vassiliki Bountziouka
1Respiratory, Critical Care & Anaesthesia Section, UCL, Institute of Child Health, London, United Kingdom
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Angela Wade
2Clinical Epidemiology, Nutrition and Biostatistics Section, UCL, Institute of Child Health, London, United Kingdom
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Jane Kirkby
3Respiratory Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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Antonio Moreno-Galdo
4Paediatric Pulmonology Unit, Hospital Vall d'Hebron, Barcelona, Spain
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Olaia SardonPrado
5Division of Pediatric Respiratory Medicine, Donostia University Hospital, San Sebastian, Spain
6Department of Paediatrics, University of the Basque Country, San Sebastian, Spain
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Joerg Mattes
7School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
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Luis Miguel Borrego
8Centro de Alergia, CUF Descobertas Hospital, Lisbon, Portugal
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Joanne Miles
3Respiratory Medicine, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
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Janet Stocks
1Respiratory, Critical Care & Anaesthesia Section, UCL, Institute of Child Health, London, United Kingdom
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Abstract

Reference equations for the RVRTC derived from “in-house” equipment were inappropriate for commercially available devices, although an interim correction factor was developed.1

Aim: to develop equipment specific reference ranges for RVRTC outcomes.

Method: RVRTC data from healthy subjects using Jaeger BabyBody or the 'RASP' systems were collated from 4 centres. Data were excluded if gestational age<37w; birthweight<2.5kg or FEV0.5 not achieved. New reference equations were derived and compared with published references1,2 using recent data from CF infants and controls.

Results: Acceptable RVRTC data from 367 healthy infants (59%boys; 92%White) on 607 tests (age range:2.7-117w) were available from London, Australia, Spain & Portugal. Prediction equations for all data were similar to those limited to White infants or Jaeger data only, thus definitive models were based on all data. When compared with the new equations, abnormalities in FVC & FEV0.5 were increasingly over-estimated with age when using Jones equations2, with a more constant overestimation for FEF25-75(Figs A-C). By contrast, the 'Jones adjusted' equations1 tended to over-estimate abnormalities in younger children but were adequate for older infants(Figs E-F).

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Conclusion: This study provides improved prediction equations for RVRTC outcomes which will enhance interpretation of infant lung function results.

1Lum PedPulm 2010

2Jones AJRCCM 2000.

  • Infants
  • Lung function testing
  • Lung growth/development
  • Copyright ©ERS 2015
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Equipment specific reference ranges for the raised volume technique (RVRTC) in infants: A multi-centre collaboration
Sooky Lum, Vassiliki Bountziouka, Angela Wade, Jane Kirkby, Antonio Moreno-Galdo, Olaia SardonPrado, Joerg Mattes, Luis Miguel Borrego, Joanne Miles, Janet Stocks
European Respiratory Journal Sep 2015, 46 (suppl 59) PA1261; DOI: 10.1183/13993003.congress-2015.PA1261

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Equipment specific reference ranges for the raised volume technique (RVRTC) in infants: A multi-centre collaboration
Sooky Lum, Vassiliki Bountziouka, Angela Wade, Jane Kirkby, Antonio Moreno-Galdo, Olaia SardonPrado, Joerg Mattes, Luis Miguel Borrego, Joanne Miles, Janet Stocks
European Respiratory Journal Sep 2015, 46 (suppl 59) PA1261; DOI: 10.1183/13993003.congress-2015.PA1261
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