Abstract
Background: The delicate mechanisms of asthma involve the activation of many inflammatory and structural cells, all of which release inflammatory mediators that result in the typical pathophysiological changes of asthma.
Aim of Work: The aim of this work is to assess lipoxin A4 and nitric oxide as mediators in bronchial asthma patients.
Patients and methods: 75 patients with mild , moderate and severe asthma, 4th and 15 healthy volunteers as a control group. Determination of serum nitrites, enzyme immunoassay for serum lipoxin A4, and latex qualitative determination of serum C-reactive protein (CRP).
Results: .
Mean+/-SD | F | P | |
Severe asthma | 60.64*#$ +/-15.03 | 20.41 | <0.001 |
Moderate asthma | 48.80*#+/-11.81 | 20.41 | <0.001 |
Mild asthma | 40.64*+/-12.43 | 20.41 | <0.001 |
Control group | 31.06+/-8.13 | 20.41 | <0.001 |
*=significant increase in nitrites in comparison to control group.#=significant increase in nitrites in comparison to mild asthma $=significant increase in nitrites in comparison to moderate asthma
Conclusion: The low serum levels of lipoxin A4 and increased level of CRP and nitrites, emphasizes the rule of imbalance in inflammatory and anti-inflammatory cytokines in severity of asthma.
- Copyright ©ERS 2015