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LATE-BREAKING ABSTRACT: A randomized controlled trial of early probiotic supplementation to prevent early markers of asthma for high-risk infants

M. Cabana, M. McKean, A. Caughey, R. Leong, A. Wong, J. Hilton, H. Boushey
European Respiratory Journal 2015 46: OA4770; DOI: 10.1183/13993003.congress-2015.OA4770
M. Cabana
1Pediatrics, Medicine, Epidemiology & Biostats, UCSF, San Francisco, CA United States
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M. McKean
1Pediatrics, Medicine, Epidemiology & Biostats, UCSF, San Francisco, CA United States
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A. Caughey
2Obstetrics & Gynecology, OHSU, Portland, OR United States
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R. Leong
3Pediatrics & Allergy, CPMC, San Francisco, CA United States
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A. Wong
4Pediatrics, Kaiser, San Francisco, CA United States
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J. Hilton
1Pediatrics, Medicine, Epidemiology & Biostats, UCSF, San Francisco, CA United States
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H. Boushey
1Pediatrics, Medicine, Epidemiology & Biostats, UCSF, San Francisco, CA United States
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Abstract

Background: Recent trials have studied the potential benefit of early probiotic supplementation with Lactobacillus GG (LGG) in decreasing the future risk of asthma in children with mixed results.

Methods: We conducted a randomized, double-blinded controlled trial (n=185) to assess the effect of early LGG supplementation on the development of asthma, eczema and recurrent wheezing for infants at high risk for asthma. For the first 6 months of life, the intervention group (n=93) received a daily dose of 10 billion colony-forming units of LGG (Amerifit;USA) and the control group (n=92) received a daily control capsule. To assess for outcomes and confounding factors (feeding practices and antibiotic exposure), data were collected monthly during the first year and semi-annually during the second year of life.

Results: After 2 years of age, the follow-up rate was 97%. 92 (50%) were Caucasian; 60 (32%) mixed race and 46 (25%) were also Hispanic. 48 (26%) were born by C-Section. 72 (38%) mothers received antibiotics during delivery. 133 (72%) infants were exclusively breastfed for the first 6 mons of life. There were no differences between the groups in terms of demographics, delivery type, infant formula or antibiotic exposure. To date, 14% (13/92) of control and 15% (14/93) of intervention infants have asthma. 28% (26/92) of control and 22% (20/93) of intervention infants have recurrent wheezing. 37% (34/92) of control and 37% (34/93) of intervention infants have eczema (p>0.05). CONCLUSIONS: For high-risk infants, early LGG supplementation for the first 6 months of life does not appear to prevent the development of asthma, eczema or recurrent wheezing at 2 yrs.

  • Allergy
  • Child
  • Public health
  • Copyright ©ERS 2015
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LATE-BREAKING ABSTRACT: A randomized controlled trial of early probiotic supplementation to prevent early markers of asthma for high-risk infants
M. Cabana, M. McKean, A. Caughey, R. Leong, A. Wong, J. Hilton, H. Boushey
European Respiratory Journal Sep 2015, 46 (suppl 59) OA4770; DOI: 10.1183/13993003.congress-2015.OA4770

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LATE-BREAKING ABSTRACT: A randomized controlled trial of early probiotic supplementation to prevent early markers of asthma for high-risk infants
M. Cabana, M. McKean, A. Caughey, R. Leong, A. Wong, J. Hilton, H. Boushey
European Respiratory Journal Sep 2015, 46 (suppl 59) OA4770; DOI: 10.1183/13993003.congress-2015.OA4770
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