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LATE-BREAKING ABSTRACT: Does grandmaternal smoking increase the risk of asthma in grandchildren?

Caroline Lodge, Adrian Lowe, Shyamali Dharmage, David Olsson, Bertil Forsberg, Lennart Bråbäck
European Respiratory Journal 2015 46: OA4762; DOI: 10.1183/13993003.congress-2015.OA4762
Caroline Lodge
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria Australia
2Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria Australia
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Adrian Lowe
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria Australia
2Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria Australia
3Department of Public Health and Clinical Medicine, Umea University, Umea, Vasterbotten County Sweden
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Shyamali Dharmage
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria Australia
2Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria Australia
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David Olsson
3Department of Public Health and Clinical Medicine, Umea University, Umea, Vasterbotten County Sweden
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Bertil Forsberg
3Department of Public Health and Clinical Medicine, Umea University, Umea, Vasterbotten County Sweden
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Lennart Bråbäck
3Department of Public Health and Clinical Medicine, Umea University, Umea, Vasterbotten County Sweden
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Abstract

Background: There is increasing interest in environmental exposures as heritable risk factors. Animal studies have linked grand-maternal nicotine exposure to lung changes in grand-offspring of unexposed mothers. This has been partially corroborated in limited human studies, although inconsistently.

Aim: To investigate the association between grand-maternal smoking during pregnancy and asthma risk in grandchildren

Methods: From 1982-1986, 44,583 grandmothers gave birth to children in Sweden. Subsequently 46,197 of these children (aka mothers) gave birth to 66,271 grandchildren (aka children) (born 1996-2000).Smoking exposure was recorded at 10-12 weeks gestation for both mothers and grandmothers. Also 3 months preconception and third trimester smoking were recorded for mothers. Purchased asthma medication was recorded for children (2005-2013). Current asthma in any year was defined as purchasing inhaled steroids. Maternal smoking, gender, county, social allowance, grand-paternal smoking, grandmothers BMI and grandmothers age, were included as covariates. There was no interaction by maternal smoking.

Results: Grandmothers smoking during pregnancy there was associated with an increased asthma risk for grandchildren from 1-6 years (Adjusted odds ratios: 1-2yr, 1.19; 95%CI 1.10,1.27; 2-3yr, 1.22; 1.14,1.31, 3-4yr, 1.11; 1.02,1.21, 4-5yr,1.10; 0.99,1.22, 5-6yr ,1.14; 1.00,1.31).

Conclusions: Children aged 1-6 years had a 10- 22% increased risk of asthma if their grandmothers smoked during early pregnancy. These findings support possible epigenetic transmission of risk from environmental exposures in previous generations.

  • Asthma - mechanism
  • Smoking
  • Public health
  • Copyright ©ERS 2015
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LATE-BREAKING ABSTRACT: Does grandmaternal smoking increase the risk of asthma in grandchildren?
Caroline Lodge, Adrian Lowe, Shyamali Dharmage, David Olsson, Bertil Forsberg, Lennart Bråbäck
European Respiratory Journal Sep 2015, 46 (suppl 59) OA4762; DOI: 10.1183/13993003.congress-2015.OA4762

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LATE-BREAKING ABSTRACT: Does grandmaternal smoking increase the risk of asthma in grandchildren?
Caroline Lodge, Adrian Lowe, Shyamali Dharmage, David Olsson, Bertil Forsberg, Lennart Bråbäck
European Respiratory Journal Sep 2015, 46 (suppl 59) OA4762; DOI: 10.1183/13993003.congress-2015.OA4762
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