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Dynamics of sputum antimicrobial peptide levels in chronic obstructive pulmonary disease (COPD)

Louise Jeanette Pauline Persson, Marianne Aanerud, Per Sigvald Bakke, Tomas Mikal Eagan, Pieter Sicco Hiemstra
European Respiratory Journal 2015 46: OA4749; DOI: 10.1183/13993003.congress-2015.OA4749
Louise Jeanette Pauline Persson
1Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
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Marianne Aanerud
2Dept. of Medicine, Haukeland University Hospital, Bergen, Norway
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Per Sigvald Bakke
3Dept. of Clinical Science, University of Bergen, Bergen, Norway
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Tomas Mikal Eagan
1Dept. of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway
3Dept. of Clinical Science, University of Bergen, Bergen, Norway
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Pieter Sicco Hiemstra
4Dept. of Pulmonology, Leiden University Medical Center, Leiden, Netherlands
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Abstract

Background: Antimicrobial peptides (AMPs) play important roles in innate lung defense against pathogens, however high concentrations may enhance inflammation in COPD.

Aims: 1) Compare sputum levels of the two AMPs hCAP18/LL-37 and SLPI in COPD to controls, and stable COPD versus exacerbation 2) Examine factors associated with AMP levels.

Methods: Repeated measurements were collected in 426 stable and 355 COPD patients when exacerbating, and 233 controls during the 3-year study period. First available induced sputum sample was selected per subject for analyses of AMP levels (enzyme linked immunosorbent assay) and inflammatory markers (bead-based immunoassay). Associations were tested by the Wilcoxon rank-sum test and Spearman's rank correlation coefficient.

Results: 255 stable and 55 exacerbation sputum samples from patients and 45 sputum samples from controls were available.

While stable, COPD patients had significantly higher AMP levels compared to controls (p≤0.01) and male sex, higher age, GOLD stage, neutrophil count and IL-8 levels in sputum were associated with higher hCAP18/LL-37 levels in COPD.

During exacerbation, sputum hCAP18/LL-37 levels were higher and SLPI levels lower (p<0.001), and inversely correlated (r=-0.48, p<0.001) compared to stable COPD. The correlation remained between sputum hCAP18/LL-37 and IL-8 (r=0.33, p=0.01) and neutrophil count (r=0.46, p<0.001). SLPI were positively correlated with IL-6 (r=0.55, p<0.001) and negatively with neutrophil count (r=-0.42, p<0.01).

Conclusion: COPD is associated with altered AMP levels, which is further changed during exacerbation. Neutrophil recruitment during exacerbation may explain changes in AMP levels during exacerbation.

  • Immunology
  • COPD - mechanism
  • Inflammation
  • Copyright ©ERS 2015
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Dynamics of sputum antimicrobial peptide levels in chronic obstructive pulmonary disease (COPD)
Louise Jeanette Pauline Persson, Marianne Aanerud, Per Sigvald Bakke, Tomas Mikal Eagan, Pieter Sicco Hiemstra
European Respiratory Journal Sep 2015, 46 (suppl 59) OA4749; DOI: 10.1183/13993003.congress-2015.OA4749

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Dynamics of sputum antimicrobial peptide levels in chronic obstructive pulmonary disease (COPD)
Louise Jeanette Pauline Persson, Marianne Aanerud, Per Sigvald Bakke, Tomas Mikal Eagan, Pieter Sicco Hiemstra
European Respiratory Journal Sep 2015, 46 (suppl 59) OA4749; DOI: 10.1183/13993003.congress-2015.OA4749
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