Abstract
Introduction and Aims: COPD is a heterogeneous syndrome marked by pulmonary obstruction and the presence of multiple comorbidities. The high incidence of cardiovascular disease in patients with COPD may be the result of common risk factors, particularly smoking, systemic inflammation and hypoxia.The aim of this work is to examine the cardiovascular status of patients with a severe form of COPD (post-BD FEV1 < 60%).
Method: The analyzed data is taken from The Czech Multicenter Database of COPD[1], a prospective study. This is the first-stage analysis at enrollment.
Results: The presence of cardiovascular disease was analyzed in 343 patients. Ischemic heart disease (IHD) was present in 25.9%, heart failure (HF) 13.7%, atrial fibrillation 13.1% and hypertension 53.9%. Cachexic patients were less likely to have hypertension and HF (p= 0.055, p=0.002 respectively). The presence of IHD was statistically significant in patients with Asthma COPD overlap syndrome (p= 0.035). The incidence of hypertension was most significant in the D category (GOLD 2011) (57.3%, p=0.036). The use of cardiovascular medications was monitored; Diuretics 38.5%, ACEI 32.9%, Antiaggregants 32.7%, Statins 28.9%, Calcium antagonists 21.3%, Amiodarone 5.5%. Betablockers are used by 23%, out of which 2.4% used a known non-selective betablocker.
Conclusions: Some COPD phenotypes seem to have a higher prevalence to certain types of comorbidities. Due to the high prevalence of heart disease in COPD patients, cardiovascular diseases should be actively searched for in clinical practice. NCT 01923051. 1. Novotna B et al. Czech multicenter research database of severe COPD. Int J Chron Obstruct Pulmon Dis. 2014 Nov 10;9:1265-74.
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