Abstract
Background: Many exposures and behavioral patterns during early life had been studied regarding asthma and respiratory health, particularly for wheezing. However, cough is very common at earlier age, and little is known about its determinants.
We aimed to determine the relation between prenatal, postnatal outcomes and cough at two months of birth, in a large representative cohort in France.
Methods: ELFE cohort is the first national population-based conducted in France, including n=16030 newborns. Using multivariate analysis (logistic regression), we examined the association between prenatal, and postnatal outcomes and cough in babies at two months of life.
Results: Prevalence of cough since birth was 25.4 %; current cough prevalence was 16.7%, with significant higher prevalence in boys than girls. Prevalence of wheezing was 6.5%. Prevalence of bronchitis was 34.6%. Maternal age (18-25 yrs) OR =1.5[1.3-1.72], being a boy OR =1.15[1.07-1.24], maternal atopy OR =1.12[1.04-1.21], and smoking during pregnancy OR =1.14[1.04-1.2] and paternal birth in foreign country OR=1.18[1.05-1.33], were significantly associated with cough.
Regarding postnatal outcomes: reflux OR =1.35[1.24-1.48], worse maternal health quality of life OR =2.09[1.38-3.17], and maternal smoking OR=1.14[1.04-1.24], size of the house OR =1.37[1.07-1.77], were significantly associated with cough.
In this national population-based cohort of newborn, a high prevalence of respiratory symptoms was found at two months of birth, with significant associations between prenatal, and post-natal outcomes and cough. Follow-up of these babies until 18 years old will provide useful information regarding respiratory phenotypes.
Fundings: INSERM-INED.
- Copyright ©ERS 2015
