Abstract
Introduction: The associations between TRAP, asthma and allergies in children are heterogeneous, possibly due to genetic polymorphisms in that modify the response to oxidative stress.
Aim: To investigate if variants in the glutathione pathway alter associations between early life TRAP exposure and childhood asthma and allergies.
Methods: Data on current asthma, wheeze and eczema were collected at ages 7, 12 and 18 years for 620 children from a high-risk birth cohort. TRAP was assessed by total major road length within 150m of the birth address. Interactions between TRAP and GSTT1, GSTM1, GSTP1 and GSTCD polymorphisms on outcomes were examined using regression models.
Results: Baseline TRAP exposure was not associated with any outcome. Carriers of GSTM1null and GSTT1null had increased risk of current asthma at 7 years (OR=1.86, 95%CI 1.10-3.15) and current eczema at 18 years (1.78, 1.04-3.03) respectively. GSTT1null carriers exposed to TRAP in early life had increased risk of wheeze (2.31, 1.17-4.57) and asthma (2.15, 1.15-4.00) at 12 years (p-interactions=0.02, 0.04 respectively) when compared to TRAP exposed carriers of wild type GSTT1. Early life TRAP exposure had a trend to increased risk of wheeze at 12 years for carriers of ile/ile in GSTP1 and at least one G allele in GSTCD (1.30, 0.97-1.74 and 1.24, 0.99-1.56 respectively). Among carriers of GSTT1null TRAP exposure was associated with increased risk of current eczema at 7 and 12 years (p-interactions=0.03, 0.06 respectively).
Conclusion: TRAP may increase risk of childhood asthma, wheeze and eczema among those carrying GSTT1null, ile/ile alleles in GSTP1 and G allele in GSTCD genes.
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