Extract
Cystic fibrosis (CF) is a genetic condition that is caused by abnormalities in the CF transmembrane conductance regulator (CFTR) gene. People with CF experience life-long morbidity and premature mortality, the vast majority of which is associated with lung disease.
Abstract
Bile acids are detectable in the lower airway in advanced CF lung disease and persist after lung transplantation http://ow.ly/RTvNW
Acknowledgements
We gratefully acknowledge the help of the patients involved in this study along with all members of the wider cardiothoracic transplantation team at the Freeman Hospital.
Footnotes
Support statement: Funding for this work was gratefully received from a Saudi Arabian government studentship (A. Aseeri, J.P. Pearson and C. Ward), Medical Research Council (MRC)/CF Trust Clinical Research Training and Clinician Scientist Fellowships (M. Brodlie), an MRC Project Grant (C. Ward and P.A. Corris), the Newcastle upon Tyne Hospitals NHS Foundation Trust Special Trustees (M.C. McKean, M. Brodlie, C. Ward and J.L. Lordan) and the British Lung Foundation Trevor Clay Memorial Award (C. Ward, J.P. Pearson and A.G.N. Robinson). Funding information for this article has been deposited with FundRef.
Conflict of interest: None declared.
- Received March 31, 2015.
- Accepted August 12, 2015.
- Copyright ©ERS 2015
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