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The problem of early mortality in pneumococcal pneumonia: a study of risk factors

Joaquín Burgos, Manel Luján, M. Nieves Larrosa, M. Luisa Pedro-Botet, Dionisia Fontanals, M. Dolores Quesada, Mayli Lung, Guadalupe Bermudo, Benito Almirante, Vicenç Falcó
European Respiratory Journal 2015 46: 561-564; DOI: 10.1183/09031936.00034415
Joaquín Burgos
1Infectious Diseases Dept, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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  • For correspondence: jburgos@vhebron.net
Manel Luján
2Pneumology Dept, Hospital de Sabadell, Corporació Sanitaria Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
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M. Nieves Larrosa
3Microbiology Dept, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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M. Luisa Pedro-Botet
4Infectious Diseases Unit, Hospital Germans Trias i Pujol de Badalona, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
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Dionisia Fontanals
5Microbiology Dept, UDIAT, Hospital de Sabadell, Corporació Sanitaria Parc Taulí, Universitat Autònoma de Barcelona, Barcelona, Spain
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M. Dolores Quesada
6Microbiology Dept, Hospital Germans Trias i Pujol de Badalona, Universitat Autònoma de Barcelona, Barcelona, Spain
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Mayli Lung
3Microbiology Dept, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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Guadalupe Bermudo
2Pneumology Dept, Hospital de Sabadell, Corporació Sanitaria Parc Taulí, Universitat Autònoma de Barcelona, CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain
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Benito Almirante
1Infectious Diseases Dept, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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Vicenç Falcó
1Infectious Diseases Dept, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain
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Tables

  • TABLE 1

    Multivariate analysis: risk factors for early and late mortality in invasive pneumococcal pneumonia

    RRR (95% CI)p-value
    Early mortality
     Age (18–50 years versus >50 years)0.48 (0.17–1.33)0.157
     Male sex1.51 (0.76–3.02)0.24
     Previous pneumococcal vaccination1.16 (0.6–2.24)0.66
     Alcohol consumption2.28 (1.11–4.66)0.024
     Chronic heart disease2.71 (1.42–5.19)0.003
     Chronic liver disease0.85 (0.35–2.05)0.713
     Chronic neurological disease2.26 (1.05–4.85)0.037
     HIV infection1.77 (0.56–5.58)0.329
     Haematologic cancer1.93 (0.73–5.09)0.182
     Solid cancer2.13 (0.96–4.73)0.062
     High case fatality rate serotypes#1.98 (1.07–3.63)0.029
    Late mortality  
     Age (18–50 years versus >50 years)0.53 (0.22–1.31)0.17
     Male sex1.22 (0.59–2.51)0.24
     Previous pneumococcal vaccination0.7 (0.32–1.52)0.366
     Alcohol consumption2.25 (1.12–4.53)0.023
     Chronic heart disease0.65 (0.24–1.76)0.401
     Chronic liver disease0.91 (0.4–2.07)0.813
     Chronic neurological disease0.96 (0.28–3.33)0.954
     HIV infection4 (1.55–10.3)0.004
     Haematologic cancer3.07 (1.21–7.76)0.018
     Solid cancer4.18 (1.96–8.92)<0.001
     High case fatality rate serotypes#1.81 (0.96–3.42)0.069
    • RRR: relative risk ratio. #: serotypes grouped as high case fatality rates are serotypes 3, 6A, 6B, 9N, 19A, 19F and 23F.

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The problem of early mortality in pneumococcal pneumonia: a study of risk factors
Joaquín Burgos, Manel Luján, M. Nieves Larrosa, M. Luisa Pedro-Botet, Dionisia Fontanals, M. Dolores Quesada, Mayli Lung, Guadalupe Bermudo, Benito Almirante, Vicenç Falcó
European Respiratory Journal Aug 2015, 46 (2) 561-564; DOI: 10.1183/09031936.00034415

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The problem of early mortality in pneumococcal pneumonia: a study of risk factors
Joaquín Burgos, Manel Luján, M. Nieves Larrosa, M. Luisa Pedro-Botet, Dionisia Fontanals, M. Dolores Quesada, Mayli Lung, Guadalupe Bermudo, Benito Almirante, Vicenç Falcó
European Respiratory Journal Aug 2015, 46 (2) 561-564; DOI: 10.1183/09031936.00034415
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