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Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2)

Lewis J. Rubin, Nazzareno Galiè, Friedrich Grimminger, Ekkehard Grünig, Marc Humbert, Zhi-Cheng Jing, Anne Keogh, David Langleben, Arno Fritsch, Flavia Menezes, Neil Davie, Hossein-Ardeschir Ghofrani
European Respiratory Journal 2015 45: 1303-1313; DOI: 10.1183/09031936.00090614
Lewis J. Rubin
1Dept of Medicine, University of California, San Diego, La Jolla, California, USA
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Nazzareno Galiè
2Dept of Experimental, Diagnostic and Specialty Medicine–DIMES, Bologna University Hospital, Bologna, Italy
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Friedrich Grimminger
3University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany
4Member of the German Center of Lung Research (DZL)
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Ekkehard Grünig
5Centre for Pulmonary Hypertension, Thoraxclinic, University Hospital Heidelberg, Heidelberg, Germany
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Marc Humbert
6Université Paris-Sud, Le Kremlin-Bicêtre, France
7AP-HP Service de Pneumologie, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
8INSERM U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis, Robinson, France
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Zhi-Cheng Jing
9State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
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Anne Keogh
10St Vincent's Hospital, Sydney, Australia
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David Langleben
11Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada
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Arno Fritsch
12Global Clinical Development, Bayer HealthCare Pharmaceuticals, Wuppertal, Germany
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Flavia Menezes
13Bayer HealthCare Pharmaceuticals, São Paulo, Brazil
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Neil Davie
12Global Clinical Development, Bayer HealthCare Pharmaceuticals, Wuppertal, Germany
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Hossein-Ardeschir Ghofrani
3University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany
4Member of the German Center of Lung Research (DZL)
14Dept of Medicine, Imperial College London, London, UK
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Article Information

vol. 45 no. 5 1303-1313
DOI 
https://doi.org/10.1183/09031936.00090614
PubMed 
25614164

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received May 16, 2014
  • Accepted November 11, 2014
  • Published online April 30, 2015.

Article Versions

  • previous version (January 22, 2015 - 06:48).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2015

Author Information

  1. Lewis J. Rubin1,
  2. Nazzareno Galiè2,
  3. Friedrich Grimminger3,4,
  4. Ekkehard Grünig5,
  5. Marc Humbert6,7,8,
  6. Zhi-Cheng Jing9,
  7. Anne Keogh10,
  8. David Langleben11,
  9. Arno Fritsch12,
  10. Flavia Menezes13,
  11. Neil Davie12 and
  12. Hossein-Ardeschir Ghofrani3,4,14
  1. 1Dept of Medicine, University of California, San Diego, La Jolla, California, USA
  2. 2Dept of Experimental, Diagnostic and Specialty Medicine–DIMES, Bologna University Hospital, Bologna, Italy
  3. 3University of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany
  4. 4Member of the German Center of Lung Research (DZL)
  5. 5Centre for Pulmonary Hypertension, Thoraxclinic, University Hospital Heidelberg, Heidelberg, Germany
  6. 6Université Paris-Sud, Le Kremlin-Bicêtre, France
  7. 7AP-HP Service de Pneumologie, DHU Thorax Innovation, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
  8. 8INSERM U999, LabEx LERMIT, Centre Chirurgical Marie Lannelongue, Le Plessis, Robinson, France
  9. 9State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
  10. 10St Vincent's Hospital, Sydney, Australia
  11. 11Center for Pulmonary Vascular Disease and Lady Davis Institute, Jewish General Hospital, McGill University, Montreal, Canada
  12. 12Global Clinical Development, Bayer HealthCare Pharmaceuticals, Wuppertal, Germany
  13. 13Bayer HealthCare Pharmaceuticals, São Paulo, Brazil
  14. 14Dept of Medicine, Imperial College London, London, UK
  1. Lewis J. Rubin, University of California, San Diego, 5550 Caminito Genio, La Jolla, CA 92037, USA. E-mail: ljr{at}lewisrubinmd.com
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Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2)
Lewis J. Rubin, Nazzareno Galiè, Friedrich Grimminger, Ekkehard Grünig, Marc Humbert, Zhi-Cheng Jing, Anne Keogh, David Langleben, Arno Fritsch, Flavia Menezes, Neil Davie, Hossein-Ardeschir Ghofrani
European Respiratory Journal May 2015, 45 (5) 1303-1313; DOI: 10.1183/09031936.00090614

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Riociguat for the treatment of pulmonary arterial hypertension: a long-term extension study (PATENT-2)
Lewis J. Rubin, Nazzareno Galiè, Friedrich Grimminger, Ekkehard Grünig, Marc Humbert, Zhi-Cheng Jing, Anne Keogh, David Langleben, Arno Fritsch, Flavia Menezes, Neil Davie, Hossein-Ardeschir Ghofrani
European Respiratory Journal May 2015, 45 (5) 1303-1313; DOI: 10.1183/09031936.00090614
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