Electronic nicotine delivery systems

To the Editor:

While reading the editorial on electronic nicotine delivery systems by Blasi and Ward [1], we noticed an inaccuracy in the section on The post-2016 regimen (p. 586). It is wrongly stated that “there will be a maximum nicotine volume for e-cigarettes of 10 mL for refillable cartridges”. The volume of 10 mL was stated by the European Union in its 2014/40/EU Directive to be applicable to “refill containers” for the e-liquids that are used to refill the (maximally) 2 mL-containing refillable cartridges of an e-cigarette [2]. In the EU Directive 2014/40/EU, it is stated in article 20.3a that “nicotine-containing liquid is only placed on the market in dedicated refill containers not exceeding a volume of 10 ml, in disposable electronic cigarettes or in single use cartridges and that the cartridges or tanks do not exceed a volume of 2 ml” and in article 20.3b that “the nicotine-containing liquid does not contain nicotine in excess of 20 mg/ml.”