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Comparison of different GC-IMS-devices for measurement of volatile biomarkers (VOC)

Gunther Becher, Roman Purkhart, Anne Hillmann, Rolf Graupner, Schueler Werner
European Respiratory Journal 2014 44: P996; DOI:
Gunther Becher
1R&D, BecherConsult GmbH, Bernau, Germany
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Roman Purkhart
2R&D, IFU GmbH, Lichtenau, Germany
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Anne Hillmann
3Fac Math. Sciences, Univ. Appl. Sci. Mittweida, Mittweida, Germany
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Rolf Graupner
4Development, Graupner Medical Solutions GmbH, Geyer, Germany
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Schueler Werner
5R&D, STEP Sensortechnik GmbH, Pockau, Germany
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Abstract

Introduction

The Ion Mobility Spectrometry (IMS) is a highly sensitive analytical method for detection of volatile organic compounds (VOCs) in air. Available studies were typically done with one device in mono-centric studies only. The aim of the study was the comparison of different devices.

Methods:

The headspaces of in vitro cultures of two strains of mycobacterium avium were measured with a GC-differential-ion-mobility-spectrometry (DMS-SIONEX) as well as with a GC-IMS Prototype (GC-IMS) 1 week after inoculation. Pure breeding grounds were measured as control. Both devices show spectra with comparable numbers of peaks. The spectra were analyzed by a statistical program based on cluster analysis.

Results

With both devices was possible a significant differentiation between control and the bacterial growth. Each cluster represents the same peaks, e.g. detected metabolite, in the different measurements. Fig. 1 shows clusters for differentiation between control (left) and strain 1 (middle) and strain 2 (right) for both devices.

Figure1
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Discussion

With both devices the differentiation between breeding ground and bacterial growth was possible with a sensitivity and specifity of 100%. The detected clusters should be verified between the devices. Differentiation between two devices will be helpful for evaluation of peaks. GC-IMS may be a more rapid tool for detection of bacterial growth in vitro than traditional methods.

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Comparison of different GC-IMS-devices for measurement of volatile biomarkers (VOC)
Gunther Becher, Roman Purkhart, Anne Hillmann, Rolf Graupner, Schueler Werner
European Respiratory Journal Sep 2014, 44 (Suppl 58) P996;

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Comparison of different GC-IMS-devices for measurement of volatile biomarkers (VOC)
Gunther Becher, Roman Purkhart, Anne Hillmann, Rolf Graupner, Schueler Werner
European Respiratory Journal Sep 2014, 44 (Suppl 58) P996;
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