Abstract
Aim: To evaluate the potential effect of Vitamin-D deficiency(VDD) on lung functions in current/ex-smoker patients with COPD.
Methods: 86-stable-COPD patients who admitted to Department of Pulmonary Disease of Cukurova University Faculty of Medicine were recruited.After obtaining clinical and demographical data, comorbidity status, MMRC-dyspnea score, BODE-index were recorded and respiratory function tests(RFT) and 6-minute walking tests were performed.High pressure liquid chromatography was used for the measurement of serum Vitamin-D levels and <20ng/ml was accepted as Vitamin-D deficiency.
Results:51-COPD patients were ex-smoker(59.3%),35 were current smoker(40.7%).Vitamin-D deficiency was determined in 48.5% of the smoker and 33.3% in ex-smoker patients. When the current smoker patients compared according to the presence of Vitamin-D deficiency, age, gender, GOLD-stage, MMRC-dyspnea score and BODE-index was comparable among two groups while in Vitamin-D deficient current smokers, smoking intensity were higher (56 ± 29 vs. 36±18 pck/years) and pre-bronchodilator FEV1(%)(44±17 vs. 56±17) and FVC(%)(60±13 vs. 76±21) were significantly lower than in patients with no VDD (p<0.05). Similarly among ex-smoker COPD patients, MMRC dyspnea score was higher(1.5±0.5 vs. 1.2±0.4), and pre-bronchodilator FEV1(L)(1.2±0.5 vs. 1.6± 0.6) and FVC(L)(2.2±0.8 vs. 2.8±0.9) were lower in Vitamin-D deficient group.
Conclusion:This study showed that Vitamin-D deficiency was associated with lower lung function.This suggest that VDD may be related to more rapid lung function decline in smokers with COPD.However, this should be confirmed with further studies performed in larger cohorts with long term follow-up.
- © 2014 ERS
