Abstract
Leukotrines are involved in the pathophysiology of asthma, contributing for inflammation, remodeling and hyperresponsiveness. Aerobic physical training (APT) inhibits asthmatic reactions and in animal models were already demonstrated that reduces even the airway inflammation and remodeling, although the mechanisms are only superficially investigated. Therefore, this study aimed to investigate if the leukotrienes are involved in these anti-inflammatory effects of APT in an asthma model induced by ovalbumin (OVA) and house dust mite (HDM). After the establishment of airway inflammation and remodeling, APT was performed in a treadmill, at moderate intensity, 5x/week, during 4 weeks. The results demonstrated that, for both OVA and HDM asthma models, APT reduces the number of total cells (p<0.05) and eosinophils in the bronchoalveolar lavage (BAL) (p<0.05), the levels of IL-5 (p<0.01) in BAL and in serum, increases the levels of IL-10 (p<0.01) in BAL and in serum, reduces the number of macrophages (p<0.05), lymphocytes (p<0.01) and eosinophils (p<0.05) in the airways wall and also the collagen fibers accumulation in the airway wall (p<0.01). APT also decreased the levels of leukotriene B4 in BAL and hyperresponsiveness to methacholine (25 and 50mg/mL). Therefore, we conclude that APT reduces asthma phenotype in OVA and HDM experimental settings and these results seems to have the involvement of leukotriene pathway.
- © 2014 ERS
