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Comparison of CT-based lobar ventilation models with 3He MRI ventilation measurements in asthmatics

Bilal Tahir, Cedric Van Holsbeke, Ireland Rob, Swift Andy, Felix Horn, Helen Marshall, Juan Parra-Robles, Ruth Hartley, Richard Kay, Brightling Chris, Jan De Backer, Wim Vos, Jim Wild
European Respiratory Journal 2014 44: P544; DOI:
Bilal Tahir
1Clinical Oncology, University of Sheffield, Sheffield, United Kingdom
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Cedric Van Holsbeke
4Respiratory, Fluidda nv, Kontich, Belgium
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Ireland Rob
1Clinical Oncology, University of Sheffield, Sheffield, United Kingdom
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Swift Andy
2Academic Radiology, University of Sheffield, Sheffield, United Kingdom
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Felix Horn
2Academic Radiology, University of Sheffield, Sheffield, United Kingdom
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Helen Marshall
2Academic Radiology, University of Sheffield, Sheffield, United Kingdom
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Juan Parra-Robles
2Academic Radiology, University of Sheffield, Sheffield, United Kingdom
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Ruth Hartley
3Institute for Lung Health, University of Leicester, Leicester, United Kingdom
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Richard Kay
5Novartis, Novartis, Basel, Switzerland
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Brightling Chris
3Institute for Lung Health, University of Leicester, Leicester, United Kingdom
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Jan De Backer
4Respiratory, Fluidda nv, Kontich, Belgium
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Wim Vos
4Respiratory, Fluidda nv, Kontich, Belgium
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Jim Wild
2Academic Radiology, University of Sheffield, Sheffield, United Kingdom
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Abstract

Introduction CT models of ventilation can be computed from expiratory and inspiratory scans by means of the relative lobar expansion. This model has been validated against SPECT [1].

Objective To compare models of lobar ventilation from CT with 3He MRI using multi-modal image registration in a population of asthma patients.

Methods 29 patients with moderate-to-severe asthma underwent breath-hold CT at TLC and FRC. CT was used to segment the lobes at FRC and TLC by identification of major fissures and these were used to calculate percentage lobar ventilation [1]. 1H and 3He MRI were acquired in the same breath at FRC+1L [2], and the 1H MRI to CT registration was applied directly to 3He MRI allowing direct comparison of lobar CT ventilation with 3He.

Results 3He MRI was successfully warped to inspiration CT using the transform from the 1H MRI and CT registration. The mean absolute difference between CT and 3He MRI ventilation across lobes was 4.8% (mean±SD for each lobe: RUL+RML=6.1±4.6%; RLL=5.0±5.7%; LUL=4.0±4.1%; LLL=4.6±3.7%).

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Conclusion This study compares percentage lobar ventilation from CT models with a direct measure of gas ventilation using 3He MRI. In so doing we validate the CT ventilation model and demonstrate that multi-modal registration allows the regional interpretation of 3He MR images on top of the underlying anatomy of the CT.

References [1]Radiol 2010;257:854-62 [2]NMR Biomed 2011;24:130-34.

  • Imaging
  • Lung mechanics
  • Physiology
  • © 2014 ERS
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Comparison of CT-based lobar ventilation models with 3He MRI ventilation measurements in asthmatics
Bilal Tahir, Cedric Van Holsbeke, Ireland Rob, Swift Andy, Felix Horn, Helen Marshall, Juan Parra-Robles, Ruth Hartley, Richard Kay, Brightling Chris, Jan De Backer, Wim Vos, Jim Wild
European Respiratory Journal Sep 2014, 44 (Suppl 58) P544;

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Comparison of CT-based lobar ventilation models with 3He MRI ventilation measurements in asthmatics
Bilal Tahir, Cedric Van Holsbeke, Ireland Rob, Swift Andy, Felix Horn, Helen Marshall, Juan Parra-Robles, Ruth Hartley, Richard Kay, Brightling Chris, Jan De Backer, Wim Vos, Jim Wild
European Respiratory Journal Sep 2014, 44 (Suppl 58) P544;
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