Abstract
Chronic Obstructive Pulmonary Disease (COPD) has a high mortality. Many indices have been developed to classify disease severity including the 2007 and 2011 GOLD classification and BODE index. However, no study has compared the prediction of mortality by those indices.
This is an observational study of 96 patients with COPD and followed prospectively for a median of 60 months. We performed at baseline pulmonary function tests, 6-minute walking test, dyspnea scale mMRC, anthropometric and questionnaire measures of exacerbations. BODE index and GOLD 2007 and GOLD 2011 classification was calculated. The capacity of all indices to predict mortality was compared using Cox proportional hazard analysis and Kaplan Meier survival cruves. A total of 55 men and 41 women were studied, of whom 50% died during a follow-up time mean of 69 +/- 37 months. The mean FEV1 was 27% +/- 5%. Statistically significant associations were observed between mortality and BODE index (p = 0.024) and male sex (p = 0.021). Cox regression analysisshowed that the only statistically significant association was with BODE (p=0,037; IC: 95% 1,024-2,17). The Kaplan-Meier curves for BODE, 2007 GOLD and GOLD ABCD were calculated and are The BODE index predicts all cause mortality better than the old GOLD classification based on FEV1 and the new ABCD grading . We also observed that patients classified as GOLD B has higher mortality than those classified as GOLD C.
- © 2014 ERS
